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Table 4 Cognitive decline according to the circadian rest-activity pattern

From: The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer’s disease patients

  Model 1 Model 2
Effect size (95% CI) p value Effect size (95% CI) p value
Intradaily variability
 Global − 0.665 (− 1.190 to − 0.140) 0.014 − 0.715 (− 1.272 to − 0.157) 0.013
 Aβ42+ − 0.522 (− 1.147 to 0.103) 0.100 − 0.717 (− 1.391 to − 0.042) 0.038
Interdaily stability
 Global − 0.266 (− 0.818 to 0.286) 0.341 − 0.205 (− 0.817 to 0.407) 0.507
 Aβ42+ − 0.108 (− 0.778 to 0.562) 0.747 0.009 (− 0.690 to 0.708) 0.979
Relative amplitude
 Global − 0.495 (− 1.025 to 0.036) 0.067 − 0.587 (− 1.192 to 0.019) 0.057
 Aβ42+ − 0.658 (− 1.278 to − 0.038) 0.038 − 0.520 (− 1.202 to 0.163) 0.132
  1. Linear regression models were performed to assess the cognitive decline according to the circadian rest-activity pattern. Model 1, unadjusted analysis; model 2, adjusted for age, sex, T-tau/Aβ42 ratio, educational level, and season of the year
  2. Aβ42 amyloid-beta protein, CI confidence interval, T-tau total-tau
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Alzheimer's Research & Therapy

ISSN: 1758-9193