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Table 4 Cognitive decline according to the circadian rest-activity pattern

From: The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer’s disease patients

 

Model 1

Model 2

Effect size (95% CI)

p value

Effect size (95% CI)

p value

Intradaily variability

 Global

− 0.665 (− 1.190 to − 0.140)

0.014

− 0.715 (− 1.272 to − 0.157)

0.013

 Aβ42+

− 0.522 (− 1.147 to 0.103)

0.100

− 0.717 (− 1.391 to − 0.042)

0.038

Interdaily stability

 Global

− 0.266 (− 0.818 to 0.286)

0.341

− 0.205 (− 0.817 to 0.407)

0.507

 Aβ42+

− 0.108 (− 0.778 to 0.562)

0.747

0.009 (− 0.690 to 0.708)

0.979

Relative amplitude

 Global

− 0.495 (− 1.025 to 0.036)

0.067

− 0.587 (− 1.192 to 0.019)

0.057

 Aβ42+

− 0.658 (− 1.278 to − 0.038)

0.038

− 0.520 (− 1.202 to 0.163)

0.132

  1. Linear regression models were performed to assess the cognitive decline according to the circadian rest-activity pattern. Model 1, unadjusted analysis; model 2, adjusted for age, sex, T-tau/Aβ42 ratio, educational level, and season of the year
  2. Aβ42 amyloid-beta protein, CI confidence interval, T-tau total-tau