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Table 3 CSF biomarkers according to the circadian rest-activity pattern

From: The circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer’s disease patients

Biomarkers Intradaily variability Interdaily stability Relative amplitude
Effect size (95% CI) p value Effect size (95% CI) p value Effect size (95% CI) p value
Aβ42
 Global 0.067 (− 0.144 to 0.277) 0.529 − 0.177 (− 0.391 to 0.038) 0.106 − 0.192 (− 0.405 to 0.020) 0.076
 Aβ42+ − 0.150 (− 0.337 to 0.037) 0.114 − 0.042 (− 0.231 to 0.147) 0.660 − 0.010 (− 0.195 to 0.175) 0.910
T-tau
 Global − 0.159 (− 0.367 to 0.050) 0.133 0.109 (− 0.109 to 0.326) 0.322 0.343 (0.139 to 0.547) 0.001
 Aβ42+ − 0.034 (− 0.315 to 0.247) 0.809 0.172 (− 0.102 to 0.445) 0.213 0.304 (0.046 to 0.561) 0.022
P-tau
 Global − 0.089 (− 0.300 to 0.122) 0.404 0.068 (− 0.151 to 0.286) 0.540 0.205 (− 0.008 to 0.418) 0.059
 Aβ42+ 0.071 (− 0.228 to 0.370) 0.636 0.095 (− 0.200 to 0.390) 0.521 0.114 (− 0.174 to 0.401) 0.431
NFL
 Global − 0.056 (− 0.298 to 0.185) 0.642 0.322 (0.076 to 0.569) 0.011 0.444 (0.212 to 0.676) 0.001
 Aβ42+ − 0.070 (− 0.389 to 0.250) 0.662 0.309 (− 0.003 to 0.620) 0.052 0.503 (0.209 to 0.797) 0.001
  1. Linear regression models adjusted by age, sex, and season of the year were performed to assess the biomarkers levels according to the circadian rest-activity pattern
  2. Aβ42 amyloid-beta protein, CI confidence interval, NF-L neurofilament light, P-tau phosphorylated-tau, T-tau total-tau