Table 3 CSF biomarkers according to the circadian rest-activity pattern
Biomarkers | Intradaily variability | Interdaily stability | Relative amplitude | |||
|---|---|---|---|---|---|---|
Effect size (95% CI) | p value | Effect size (95% CI) | p value | Effect size (95% CI) | p value | |
Aβ42 | ||||||
Global | 0.067 (− 0.144 to 0.277) | 0.529 | − 0.177 (− 0.391 to 0.038) | 0.106 | − 0.192 (− 0.405 to 0.020) | 0.076 |
Aβ42+ | − 0.150 (− 0.337 to 0.037) | 0.114 | − 0.042 (− 0.231 to 0.147) | 0.660 | − 0.010 (− 0.195 to 0.175) | 0.910 |
T-tau | ||||||
Global | − 0.159 (− 0.367 to 0.050) | 0.133 | 0.109 (− 0.109 to 0.326) | 0.322 | 0.343 (0.139 to 0.547) | 0.001 |
Aβ42+ | − 0.034 (− 0.315 to 0.247) | 0.809 | 0.172 (− 0.102 to 0.445) | 0.213 | 0.304 (0.046 to 0.561) | 0.022 |
P-tau | ||||||
Global | − 0.089 (− 0.300 to 0.122) | 0.404 | 0.068 (− 0.151 to 0.286) | 0.540 | 0.205 (− 0.008 to 0.418) | 0.059 |
Aβ42+ | 0.071 (− 0.228 to 0.370) | 0.636 | 0.095 (− 0.200 to 0.390) | 0.521 | 0.114 (− 0.174 to 0.401) | 0.431 |
NF− L | ||||||
Global | − 0.056 (− 0.298 to 0.185) | 0.642 | 0.322 (0.076 to 0.569) | 0.011 | 0.444 (0.212 to 0.676) | 0.001 |
Aβ42+ | − 0.070 (− 0.389 to 0.250) | 0.662 | 0.309 (− 0.003 to 0.620) | 0.052 | 0.503 (0.209 to 0.797) | 0.001 |