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Table 2 Characteristics of Nijmegen aMCI/AD patients and controls

From: Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy

  aMCI (n = 19) AD (n = 40) Controls (n = 32) p-value
Age (years) 72 [70–78] 74 [65–77] 61 [56–67] p < 0.0001a
Sex, M/F (n) 7/12 11/29 15/17 p = 0.24b
MMSE score 26 [23–27] 20 [17–24] N.A. p < 0.0001a
APOE genotype ε4+: n = 10
ε4−: n = 3
N.A.: n = 6
ε4+: n = 0
ε4−: n = 8
N.A.: n = 2
N.A. p = 0.58b
TP (mg/ml) 0.87 [0.79–0.93] 0.85 [0.76–0.96] 0.91 [0.79–.02] p = 0.51a
T-tau (pg/ml) 504 [419–691] 627 [321–956] 267 [179–386] p < 0.0001a
P-tau (pg/ml) 91.0 [71.0–114.0] 97.5 [79–129] 47.5 [32.3–56.8] p < 0.0001a
Aβ42 (pg/ml) 459 [404-516] 468 [389–564] 864 [664–1142] p < 0.0001a
NLK (ng/ml) 4.66 ± 1.40 4.84 ± 1.58 3.07 ± 1.2 p < 0.0001d
GCA score n = 7; 2 [2–2] n = 28; 1.5 [1–2] n = 4; 0.5 [0–1] p = 0.006c
Mean MTA n = 5; 1.5 [1–2.25] n = 28; 1 [1–2] n = 2; 0 [0–0] p = 0.125c
  1. Medians and [IQR] are reported for all characteristics and markers, except for NLK (mean ± SD) and sex (n). T-tau, P-tau, Aβ42, and NLK were measured in CSF
  2. Abbreviations: AD Alzheimer’s disease, Aβ42 amyloid beta-42, APOE Apolipoprotein E, aMCI amnestic mild cognitive impairment, F female, GCA global cortical atrophy, IQR interquartile range, M male, MMSE Mini-Mental State Examination, MTA medial temporal lobe atrophy, N.A. not available, NLK neuroleukin, P-tau phosphorylated tau, SD standard deviation, TP total protein, T-tau total tau
  3. aKruskal-Wallis test
  4. bChi-square test
  5. cFisher’s exact test
  6. dANOVA