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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy

Fig. 1

CSF NLK levels in the sporadic CAA patients and controls (A) and in the aMCI/AD patients and controls (BE), with and without stratification for AT(N) status. Box and scatterplots in all panels (depicting median, interquartile range and range). A NLK levels in CAA patients and controls. The NLK levels were similar (p = 0.95). B CSF NLK levels in aMCI patients, AD patients, and controls from Nijmegen. These levels were increased in aMCI (p = 0.001) and AD patients (p < 0.0001) compared to controls. C NLK levels in A+T+(N+) aMCI/AD patients and A−T−(N−) controls from Nijmegen. NLK levels were significantly higher in A+T+(N+) aMCI/AD patients (p < 0.0001). D CSF NLK levels in aMCI patients, AD patients, and controls from Barcelona. Levels were significantly higher in aMCI patients (p < 0.0001) and AD patients (p < 0.0001) compared to controls. E NLK levels in A+T+(N+) aMCI/AD patients and A−T−(N−) controls from Barcelona. NLK levels were significantly higher in A+T+(N+) aMCI/AD patients (p < 0.0001). Abbreviations: AD, Alzheimer’s disease; CAA, cerebral amyloid angiopathy; CSF, cerebrospinal fluid; aMCI, amnestic mild cognitive impairment; ns, non-significant. **p < 0.01, ***p < 0.001

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