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Table 2 Effect of the THERAD intervention vs control on primary and secondary outcomes: change from baseline to 2, 6 and 12 months (using linear mixed models in modified intention-to-treat population for continuous outcomes, and logistic mixed models in intention-to-treat population for binary outcomes)

From: Impact of an educational programme on Alzheimer’s disease patients’ quality of life: results of the randomized controlled trial THERAD

  Estimated change from baseline
meana or ORb (95%CI)
Estimated differences in change from baseline
mean or ORb (95%CI)
p value
Estimated change from baseline
meana or ORb (95%CI)
Estimated differences in change from baseline
mean or ORb (95%CI)
p value
Estimated change from baseline
meana or ORb (95%CI)
Estimated differences in change from baseline
mean or ORb (95%CI)
p value
Outcome Intervention Control Intervention vs Control Intervention Control Intervention vs Control Intervention Control Intervention vs Control
  M2–M0 M6–M0 M12–M0
QOL patient by caregiver 0.77 [− 0.13 to 1.66] 0.09 [− 0.83 to 1.00] 0.68 [− 0.60 to 1.96]
p = 0.2970
0.15 [− 0.65 to 0.94] − 0.18 [− 0.98 to 0.62] 0.33 [− 0.80 to 1.46]
p = 0.5651
− 0.78 [− 1.93 to 0.38] − 0.59 [− 1.78 to 0.61] − 0.19 [− 1.85 to 1.47]
p = 0.8198
QOL patient by patient 0.72 [− 0.44 to 1.88] − 0.98 [− 2.19 to 0.24] 1.70 [0.01 to 3.38]
p = 0.0483
0.96 [0.00 to 1.91] − 0.78 [− 1.80 to 0.23] 1.74 [0.34 to 3.15]
p = 0.0154
1.32 [0.07 to 2.56] − 0.50 [− 1.89 to 0.89] 1.82 [− 0.06 to 3.69]
p = 0.0575
NPI f*g − 2.52 [− 6.32 to 1.29] 0.26 [− 3.51 to 4.03] − 2.77 [− 8.13 to 2.59]
p = 0.3090
− 2.64 [− 5.90 to 0.61] 1.09 [− 2.18 to 4.35] − 3.73 [− 8.34 to 0.89]
p = 0.1126
− 2.83 [− 6.89 to 1.23] 2.33 [− 1.94 to 6.60] − 5.16 [− 11.05 to 0.73]
p = 0.0859
ADL − 0.09 [− 0.20 to 0.02] − 0.15 [− 0.25 to − 0.04] 0.06 [− 0.09 to 0.21]
p = 0.4519
− 0.23 [− 0.32 to − 0.13] − 0.24 [− 0.33 to − 0.15] 0.02 [− 0.12 to 0.15]
p = 0.8150
− 0.43 [− 0.59 to − 0.27] − 0.38 [− 0.54 to − 0.23] − 0.05 [− 0.27 to 0.18]
p = 0.6855
IADL (≥ 4 vs < 4 incapacities) 1.60 [1.10 to 2.31] 1.46 [1.04 to 2.06] 1.09 [0.69 to 1.72]
p = 0.7096
4.07 [1.34 to 12.31] 3.14 [1.13 to 8.69] 1.30 [0.33 to 5.11]
p = 0.7096
16.53 [1.80 to 151.63] 9.83 [1.28 to 75.52] 1.68 [0.11 to 26.12]
p = 0.7096
MMSE − 0.38 [− 0.95 to 0.19] − 0.76 [− 1.32 to − 0.19] 0.38 [− 0.43 to 1.18]
p = 0.3560
− 1.08 [− 1.63 to − 0.52] − 1.07 [− 1.61 to − 0.53] − 0.01 [− 0.79 to 0.77]
p = 0.9825
− 2.12 [− 2.92 to − 1.32] − 1.53 [− 2.31 to − 0.76] − 0.59 [− 1.71 to 0.53]
p = 0.3007
One leg balance (abnormal vs normal) 1.00 [0.87 to 1.14] 1.08 [0.93 to 1.25] 0.92 [0.76 to 1.13]
p = 0.4282
0.99 [0.65 to 1.50] 1.26 [0.82 to 1.94] 0.79 [0.43 to 1.43]
p = 0.4282
0.98 [0.42 to 2.25] 1.58 [0.67 to 3.76] 0.62 [0.19 to 2.04]
p = 0.4282
Zarit − 2.38 [− 4.50 to − 0.25] − 0.14 [− 2.24 to 1.96] − 2.24 [− 5.23 to 0.75]
p = 0.1411
− 1.19 [− 3.18 to 0.80] 0.35 [− 1.62 to 2.31] − 1.54 [− 4.33 to 1.26]
p = 0.2786
0.58 [− 2.30 to 3.46] 1.07 [− 1.79 to 3.92] − 0.49 [− 4.54 to 3.57]
p = 0.8128
Mini-GDS (≥ 1 vs =0) 1.02 [0.86 to 1.22] 0.89 [0.74 to 1.06] 1.15 [0.89 to 1.48]
p = 0.2759
1.06 [0.63 to 1.80] 0.70 [0.41 to 1.19] 1.52 [0.71 to 3.22]
p = 0.2759
1.13 [0.39 to 3.26] 0.49 [0.17 to 1.43] 2.30 [0.51 to 10.39]
p = 0.2759
NHP − 0.59 [− 14.48 to 13.30] − 6.38 [− 20.02 to 7.27] 5.79 [− 13.68 to 25.26]
p = 0.5582
2.57 [− 11.03 to 16.17] 1.95 [− 11.34 to 15.23] 0.62 [− 18.39 to 19.64]
p = 0.9484
7.31 [− 12.99 to 27.60] 14.43 [− 5.37 to 34.23] − 7.12 [− 35.48 to 21.23]
p = 0.6199
  1. aMean (95%CI): estimated with the mean values at baseline
  2. bOdds ratio (95%CI)