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Table 2 Comparison of selected dementia risk models

From: Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6

 

Cardiovascular Risk Factors, Aging and Dementia (CAIDE) score

Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI)

Brief Dementia Screening Indicator (BDSI)

Development sample age range

39–64

Variable (population based)

65+

Development sample size

1409

903–2496

1125–13889

Mean length of follow-up, years

21

Variable (population based)

6

Accuracy (area under the curve or C-statistic)**

0.77–0.78

0.64–0.74

0.68–0.78

Demographic predictors

 Age

 Sex

 

 Education*

Functional impairment

 Difficulty with instrumental activities of daily living

  

Health predictors

 Systolic blood pressure*

  

 Body mass index*

 

 Total cholesterol

  

 Diabetes*

 

 Stroke

  

 Traumatic brain injury*

 

 

 Depression*/depressive symptoms

 

Lifestyle predictors

 Smoking*

 

 

 Physical activity*

 

 Social isolation*

 

 

 Cognitively stimulating activities

 

 

 Alcohol*

 

 

 Fish intake

 

 

Genetic predictors

APOE e4 carrier

  
  1. *Modifiable risk factor identified in the 2020 Report of the Lancet Commission [8]
  2. **Range includes the development and validation test results