Table 1 Differences in bile acid metabolites and their specific ratios between control and AD groups. Means are expressed in nanomolar or as a ratio of the concentrations. Metabolites and their ratio are stratified by the metabolic affiliations. All tested bile acids and their ratios are presented in Table S3

 CA

0.0321

27.4 [20.8–36.2]

19.3 [13.6–27.4]

 CDCA

0.978

38.7 [29.2–51.5]

46.7 [32.6–66.9]

 CA/CDCA

0.0008

0.707 [0.571–0.876]

0.363 [0.271–0.487]

 GCDCA/GDCA

0.5

2.08 [1.66–2.61]

1.97 [1.51–2.57]

 TDCA/TLCA

0.0114

1.33 [1.1–1.62]

1.81 [1.49–2.21]

 GDCA/DCA

0.0031

0.719 [0.604–0.856]

1.05 [0.836–1.33]

 TDCA/DCA

0.1

0.0605 [0.0467–0.0783]

0.0777 [0.0556–0.109]

 GCA/CA

0.0104

2.52 [1.86–3.39]

4.13 [2.84–6.01]

 TCA/CA

0.076

0.506 [0.358–0.716]

0.711 [0.434–1.16]

 GUDCA/UDCA

0.7

0.546 [0.341–0.876]

0.515 [0.334–0.793]

 TUDCA/UDCA

0.746

2.83 [1.93–4.17]

2.04 [1.33–3.13]

 GCDCA/CDCA

0.491

8.15 [6.21–10.7]

8.36 [5.68–12.3]

 TCDCA/CDCA

0.644

0.734 [0.53–1.01]

0.687 [0.433–1.09]

 TLCA/LCA

0.961

0.282 [0.2–0.396]

0.252 [0.182–0.347]

 GLCA/LCA

0.721

0.711 [0.53–0.955]

0.749 [0.552–1.02]

 DCA/CA

0.0459

8.01 [5.8–11.1]

12 [7.89–18.1]

 TDCA/CA

0.0056

0.469 [0.309–0.711]

0.906 [0.517–1.59]

 GDCA/CA

0.0007

5.76 [4.01–8.27]

12.5 [7.71–20.2]

 LCA/CDCA

0.451

0.66 [0.419–1.04]

0.589 [0.42–0.825]

 UDCA/CDCA

0.691

1.39 [0.815–2.36]

1.94 [1.23–3.07]

 TUDCA

0.0275

1.07 [0.78–1.48]

1.92 [1.53–2.41]