Fig. 5

Predictive model for AD with plasma and CSF metabolites. Predictive model built independently for plasma (left) and CSF (middle) and plasma + CSF (right). Effect summary shows metabolite model components, sorted by their contribution to the model, with key pathways colored in yellow (fatty acid ethanolamides) and blue (cytochrome p450/soluble epoxide hydrolase pathway). The receiver operating characteristic (ROC) curve for the training set, together with the area under the curve (AUC) and the n for the training (T) and the validation (V) cohorts, are showed in the bottom panel. Metabolite selection through the stepwise logistic regression model together with validation cohort parameters is provided in Table S7