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Fig. 9 | Alzheimer's Research & Therapy

Fig. 9

From: High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation

Fig. 9

Effect of humanized anti–GPIIIa49-66 scFv Ab (A11) on cerebral vascular permeability. a Representative photomicrograph showing that A11dose-dependently inhibited fibrillar Aβ aggregate formation in the cultures of platelets from HFD-treated 3 × Tg mice in culture with Aβ40 compared to irrelevant control scFv Ab. Scale bar, 20 μm. b Quantification of the numbers of fibrillar Aβ aggregates (n = 4 culture wells/dose). c Quantification of Evans blue extravasated in the brain tissues of different groups. Each dot or square represents one individual. d Freezing responses of both A11 and control scFv Ab treatment during cued fear conditioning. Each dot or square represents one individual (n = 8–9/group). Data are expressed as mean ± SD, unpaired Student t test, two-tailed. *p < 0.05; n.s., not significant

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Alzheimer's Research & Therapy

ISSN: 1758-9193