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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation

Fig. 5

Increased cerebral vascular permeability in HFD-treated 3 × Tg mice. a Representative images showing cerebral vascular permeability through simple visualization of brain sections under the excitation of 550 nm by fluorescence microscope. Scale bar, 20 μm. Evans blue is a diazo salts fluorescent dye with high affinity for albumin, and Evans blue bound albumin presents red fluorescence under the excitation of 550 nm. b Quantification of Evans blue extravasated in brain tissues as described in the methods. Each symbol represents one individual (n =5/group). Data are expressed as mean ± SD, one-way ANOVA. ****p < 0.0001, n.s., not significant

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Alzheimer's Research & Therapy

ISSN: 1758-9193