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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation

Fig. 2

Increased blood coagulation, platelet size, and platelet production in HFD-treated 3 × Tg mice. a–c Mouse tail bleeding times (a), peripheral blood platelet counts (b), and mean platelet volume (MPV) (c) in 12-month-old HFD-treated 3 × Tg mice, normal chow-treated 3 × Tg mice, and B6129S wild-type (WT) mice (n = 14/group). d Serum IL-6 levels in 12-month-old 3 × Tg mice after different treatment (n = 11–12/group). e qRT-PCR analysis of thrombopoietin (Tpo) mRNA from the livers of 12-month-old 3 × Tg mice after different treatment (n = 5/group). The relative quantity of Tpo mRNA was normalized to that of the housekeeping gene Gapdh using the ΔΔCt method. f Serum TPO levels in 12-month-old 3 × Tg mice after different treatment (n = 12/group). Each dot or square represents one individual. Data are expressed as mean ± SD, one-way ANOVA (ac) or unpaired Student t test, two-tailed (df). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s., not significant

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