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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation

Fig. 1

High-fat diet (HFD)-induced atherosclerosis facilitates memory deficits. a Treatment protocols to induce atherosclerosis in 3 × Tg mice. N, normal chow; H, High-fat diet. b Serum total cholesterol (TC) in 12-month-old 3 × Tg mice after different treatment (n = 14/group). c Representative images of en face oil red O staining of artery plaque area in thoracic-abdominal aorta (TA) of 12-month-old 3 × Tg mice after different treatment. d Quantification of the plaque area of TA by ImageJ version 1.50i (n = 5/group). e Body weight after different treatment (n = 14/group). f Diagram of methods for hippocampus-dependent contextual fear conditioning. After training, mice were allowed to explore 3 min in shock chamber (Contextual test). g Freezing responses of both HFD-treated 3 × Tg mice (n = 9) and normal chow-treated mice (n = 12) during cued fear conditioning. Each dot or square represents one individual. Data are expressed as mean ± SD, unpaired Student t test, two-tailed. ***p < 0.001, n.s., not significant

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