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Table 1 Demographics and participant characteristics. For each participant, digital voice recordings of neuropsychological examinations were collected. A, B and C show the demographics of the participants with normal cognition, mild cognitive impairment, and dementia, respectively, at the time of the voice recordings. Here, N represents the number of unique participants. The mean age (± standard deviation) is reported at the time of the recordings. Mean MMSE scores (± standard deviation) were computed closest to the time of the voice recording. For cognitively normal participants, ApoE data was unavailable for one Generation 1 (Gen 1) participant and eight Generation (Gen) 2 participants; MMSE data was not collected on Generation (Gen) 3 participants. For MCI participants, ApoE data was unavailable for one Gen 1 participant, six Gen 2 participants, and one New Offspring Spouse Cohort (NOS) participant; MMSE data was also not collected for OmniGen2 and NOS participants and was not available for one Gen 1 participant. For demented participants, ApoE data was unavailable for six Gen 1 participants and three Gen 2 participants; MMSE data was not collected for Gen 3, OmniGen2, and NOS participants and not available for one Gen 1 participant

From: Detection of dementia on voice recordings using deep learning: a Framingham Heart Study

Cohort

N

Female

ApoE4+

Recordings

Age (years)

Mean MMSE

(A) Normal cases

 Gen 1

42

28

6

75

90.9 ± 3.0

27.5 ± 2.0

 Gen 2

238

117

40

392

73.9 ± 7.8

28.1 ± 2.0

 Gen 3

4

1

0

7

60.4 ± 11.5

NA

 OmniGen 1

7

2

2

9

71.4 ± 9.3

26.6 ± 2.6

 Total

291

148

48

483

76.3 ± 9.8

27.9 ± 2.0

(B) MCI cases

 Gen 1

64

47

13

85

91.4 ± 3.1

26.0 ± 2.4

 Gen 2

235

124

67

353

79.3 ± 6.8

27.2 ± 2.2

 Gen 3

1

0

0

1

60.0 ± 0.0

NA

 OmniGen 1

6

1

1

7

73.1 ± 6.8

25.3 ± 2.3

 OmniGen 2

1

1

1

1

74.0 ± 0.0

NA

 NOS

2

1

0

4

86.5 ± 5.3

NA

 Total

309

174

82

451

81.5 ± 8.0

26.9 ± 2.3

(C) Dementia cases

 Gen 1

78

56

16

99

92.2 ± 3.1

21.3 ± 5.7

 Gen 2

139

84

40

224

82.1 ± 6.7

23.3 ± 5.5

 Gen 3

1

0

0

1

80.0 ± 0.0

NA

 OmniGen 1

3

1

0

4

71.5 ± 1.7

24.8 ± 1.5

 OmniGen 2

1

1

1

1

77.0 ± 0.0

NA

 NOS

1

1

0

1

80.0 ± 0.0

NA

 Total

223

143

57

330

84.9 ± 7.6

22.7 ± 5.6