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Table 3 Estimated associations with the rate of change of underlying cognitive ability and functional dependency (n = 297), COGICARE study

From: Dynamic reciprocal relationships between cognitive and functional declines along the Alzheimer’s disease continuum in the prospective COGICARE study

  Change over time of cognitive ability Change over time of functional dependency
  Coefficient* 95% CI Coefficient* 95% CI
Intercept − 0.247 − 0.371 − 0.122 0.201 − 0.370 0.772
Clinical stage       
 CN 0 -   0 -  
 MCI 0.176 0.021 0.332 0.194 − 0.223 0.611
 AD 0.377 − 0.031 0.785 2.166 0.784 3.549
Age at baseline
 ≤ 79.6 0 -   0 -  
 79.60–82.60 − 0.021 − 0.165 0.124 − 0.144 − 0.552 0.264
 82.60–85.12 − 0.040 − 0.191 0.110 − 0.091 − 0.508 0.325
 85.12–88.34 0.003 − 0.141 0.148 0.175 − 0.248 0.599
 > 88.34 0.043 − 0.119 0.204 0.732 0.114 1.349
APOE ε4 carrier       
 No 0 -   0 -  
 Yes − 0.017 − 0.139 0.104 − 0.211 − 0.582 0.159
Sex
 Male 0 -   0 -  
 Female 0.061 − 0.036 0.157 0.117 − 0.201 0.436
Education level       
 > Primary school 0 -   0 -  
 ≤ Primary school 0.239 0.124 0.355 − 0.471 − 0.828 − 0.114
Current functional level**
 CN − 0.086 − 0.254 0.082 − 1.105 − 1.943 − 0.267
 MCI − 0.010 − 0.141 0.122 − 0.643 − 1.247 − 0.038
 AD − 0.032 − 0.160 0.096 − 0.877 − 1.484 − 0.269
 CN × time 0.032 − 0.035 0.100    
 MCI × time − 0.008 − 0.057 0.042    
 AD × time 0.033 − 0.003 0.069    
Current cognitive level**
 CN 0.154 0.052 0.255 − 0.403 − 0.783 − 0.023
 MCI 0.185 0.081 0.290 − 0.307 − 0.609 − 0.006
 AD 0.235 0.130 0.340 − − 0.342 − 0.601 − − 0.083
 CN × time     − 0.281 − 0.468 − 0.095
 MCI × time     − 0.215 − 0.413 − 0.018
 AD × time     − 0.043 − 0.099 0.014
  1. *One unit corresponds to an annual change of the same size as one standard deviation of the dimension at baseline in the reference category (CN men with a higher educational level and less than 79.6 years old at baseline)
  2. **One unit corresponds to the standard deviation of the dimension at baseline in the reference category (CN men with a higher educational level and less than 79.6 years old at baseline)