Dynamic reciprocal relationships between cognitive and functional declines along the Alzheimer’s disease continuum in the prospective COGICARE study

Table 3 Estimated associations with the rate of change of underlying cognitive ability and functional dependency (n = 297), COGICARE study

	Change over time of cognitive ability			Change over time of functional dependency
	Coefficient*	95% CI		Coefficient*	95% CI
Intercept	− 0.247	− 0.371	− 0.122	0.201	− 0.370	0.772
Clinical stage
CN	0	-		0	-
MCI	0.176	0.021	0.332	0.194	− 0.223	0.611
AD	0.377	− 0.031	0.785	2.166	0.784	3.549
Age at baseline
≤ 79.6	0	-		0	-
79.60–82.60	− 0.021	− 0.165	0.124	− 0.144	− 0.552	0.264
82.60–85.12	− 0.040	− 0.191	0.110	− 0.091	− 0.508	0.325
85.12–88.34	0.003	− 0.141	0.148	0.175	− 0.248	0.599
> 88.34	0.043	− 0.119	0.204	0.732	0.114	1.349
APOE ε4 carrier
No	0	-		0	-
Yes	− 0.017	− 0.139	0.104	− 0.211	− 0.582	0.159
Sex
Male	0	-		0	-
Female	0.061	− 0.036	0.157	0.117	− 0.201	0.436
Education level
> Primary school	0	-		0	-
≤ Primary school	0.239	0.124	0.355	− 0.471	− 0.828	− 0.114
Current functional level**
CN	− 0.086	− 0.254	0.082	− 1.105	− 1.943	− 0.267
MCI	− 0.010	− 0.141	0.122	− 0.643	− 1.247	− 0.038
AD	− 0.032	− 0.160	0.096	− 0.877	− 1.484	− 0.269
CN × time	0.032	− 0.035	0.100
MCI × time	− 0.008	− 0.057	0.042
AD × time	0.033	− 0.003	0.069
Current cognitive level**
CN	0.154	0.052	0.255	− 0.403	− 0.783	− 0.023
MCI	0.185	0.081	0.290	− 0.307	− 0.609	− 0.006
AD	0.235	0.130	0.340	− − 0.342	− 0.601	− − 0.083
CN × time				− 0.281	− 0.468	− 0.095
MCI × time				− 0.215	− 0.413	− 0.018
AD × time				− 0.043	− 0.099	0.014

*One unit corresponds to an annual change of the same size as one standard deviation of the dimension at baseline in the reference category (CN men with a higher educational level and less than 79.6 years old at baseline)
**One unit corresponds to the standard deviation of the dimension at baseline in the reference category (CN men with a higher educational level and less than 79.6 years old at baseline)

ISSN: 1758-9193