| |
Change over time of cognitive ability
|
Change over time of functional dependency
|
|---|
| |
Coefficient*
|
95% CI
|
Coefficient*
|
95% CI
|
|---|
|
Intercept
|
− 0.247
|
− 0.371
|
− 0.122
|
0.201
|
− 0.370
|
0.772
|
|
Clinical stage
| | | | | | |
|
CN
|
0
|
-
| |
0
|
-
| |
|
MCI
|
0.176
|
0.021
|
0.332
|
0.194
|
− 0.223
|
0.611
|
|
AD
|
0.377
|
− 0.031
|
0.785
|
2.166
|
0.784
|
3.549
|
|
Age at baseline
|
|
≤ 79.6
|
0
|
-
| |
0
|
-
| |
|
79.60–82.60
|
− 0.021
|
− 0.165
|
0.124
|
− 0.144
|
− 0.552
|
0.264
|
|
82.60–85.12
|
− 0.040
|
− 0.191
|
0.110
|
− 0.091
|
− 0.508
|
0.325
|
|
85.12–88.34
|
0.003
|
− 0.141
|
0.148
|
0.175
|
− 0.248
|
0.599
|
|
> 88.34
|
0.043
|
− 0.119
|
0.204
|
0.732
|
0.114
|
1.349
|
|
APOE ε4 carrier
| | | | | | |
|
No
|
0
|
-
| |
0
|
-
| |
|
Yes
|
− 0.017
|
− 0.139
|
0.104
|
− 0.211
|
− 0.582
|
0.159
|
|
Sex
|
|
Male
|
0
|
-
| |
0
|
-
| |
|
Female
|
0.061
|
− 0.036
|
0.157
|
0.117
|
− 0.201
|
0.436
|
|
Education level
| | | | | | |
|
> Primary school
|
0
|
-
| |
0
|
-
| |
|
≤ Primary school
|
0.239
|
0.124
|
0.355
|
− 0.471
|
− 0.828
|
− 0.114
|
|
Current functional level**
|
|
CN
|
− 0.086
|
− 0.254
|
0.082
|
− 1.105
|
− 1.943
|
− 0.267
|
|
MCI
|
− 0.010
|
− 0.141
|
0.122
|
− 0.643
|
− 1.247
|
− 0.038
|
|
AD
|
− 0.032
|
− 0.160
|
0.096
|
− 0.877
|
− 1.484
|
− 0.269
|
|
CN × time
|
0.032
|
− 0.035
|
0.100
| | | |
|
MCI × time
|
− 0.008
|
− 0.057
|
0.042
| | | |
|
AD × time
|
0.033
|
− 0.003
|
0.069
| | | |
|
Current cognitive level**
|
|
CN
|
0.154
|
0.052
|
0.255
|
− 0.403
|
− 0.783
|
− 0.023
|
|
MCI
|
0.185
|
0.081
|
0.290
|
− 0.307
|
− 0.609
|
− 0.006
|
|
AD
|
0.235
|
0.130
|
0.340
|
− − 0.342
|
− 0.601
|
− − 0.083
|
|
CN × time
| | | |
− 0.281
|
− 0.468
|
− 0.095
|
|
MCI × time
| | | |
− 0.215
|
− 0.413
|
− 0.018
|
|
AD × time
| | | |
− 0.043
|
− 0.099
|
0.014
|
- *One unit corresponds to an annual change of the same size as one standard deviation of the dimension at baseline in the reference category (CN men with a higher educational level and less than 79.6 years old at baseline)
- **One unit corresponds to the standard deviation of the dimension at baseline in the reference category (CN men with a higher educational level and less than 79.6 years old at baseline)
