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Table 2 Estimated associations with the underlying cognitive ability and functional dependency level at baseline (n = 297), COGICARE study

From: Dynamic reciprocal relationships between cognitive and functional declines along the Alzheimer’s disease continuum in the prospective COGICARE study

  Cognitive ability at baseline Functional dependency at baseline
  Coefficient* 95% confidence interval Coefficient* 95% confidence interval
Clinical stage by education level
Higher than primary school       
 CN 0 -   0 -  
 MCI − 0.882 − 1.284 − 0.480 0.171 − 0.275 0.617
 AD − 2.878 − 3.419 − 2.337 1.974 1.415 2.532
Lower or equal to primary school
 CN − 0.868 − 1.308 − 0.429 0.188 − 0.417 0.793
 MCI − 1.531 − 2.044 − 1.018 0.089 − 0.412 0.591
 AD − 3.572 − 4.219 − 2.926 2.811 2.105 3.518
Age at baseline
 ≤ 79.1 0 -   0 -  
 79.1–82.0 − 0.284 − 0.680 0.113 0.069 − 0.396 0.534
 82.0–84.5 − 0.461 − 0.870 − 0.053 0.304 − 0.167 0.775
 84.5–87.7 − 0.288 − 0.691 0.116 0.284 − 0.200 0.767
 > 87.7 − 0.754 − 1.146 − 0.362 1.028 0.508 1.549
APOE ε4 carrier
 No       
 Yes − 0.010 − 0.351 0.331 − 0.355 − 0.741 0.031
Sex
 Male       
 Female − 0.016 − 0.270 0.238 0.316 − 0.017 0.650
  1. *One-unit difference corresponds to the standard deviation of the dimension at baseline in the category reference (CN men with a higher educational level and less than 79.6 years old at baseline)