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Table 2 Performance of the linear and gradient boosting regressions, predicting change in MMSE 2 and 4 years after baseline for three different cohort selections. We compare models trained on features a) the all features set from baseline and b) from baseline cognitive scores only

From: Predicting progression and cognitive decline in amyloid-positive patients with Alzheimer’s disease

R2 (SD) 2-year follow-up 4-year follow-up
All features
LR, Aβ only 0.372 (0.081) 0.205 (0.227)
LR, all subjects 0.354 (0.083) 0.325 (0.134)
LR, all subjects, weighted 0.388 (0.073) 0.304 (0.152)
GB, Aβ only 0.287 (0.124) 0.156 (0.244)
GB, all subjects 0.356 (0.108) 0.252 (0.191)
GB, all subjects, weighted 0.338 (0.950) 0.263 (0.192)
Cognitive tests only
LR, Aβ only 0.343 (0.087) 0.178 (0.203)
LR, all subjects 0.333 (0.081) 0.228 (0.143)
LR, all subjects, weighted 0.350 (0.079) 0.225 (0.160)
GB, Aβ only 0.272 (0.133) − 0.050 (0.358)
GB, all subjects 0.323 (0.118) 0.149 (0.224)
GB, all subjects, weighted 0.293 (0.114) 0.118 (0.227)