Fig. 2
From: Probability of Alzheimer’s disease based on common and rare genetic variants
Combined probability of AD calculated with 2% lifetime prevalence of AD, 10% prevalence of AD in 65+ age group, including probability due to presence of a rare high-effect variant. The rare variant effect sizes and minor allele frequencies correspond to known variants in SORL1 (OR = 7.2) [25] and TREM2 (OR = 2.46) [7] genes. In age group 65+ (red) the presence of SORL1 mutations (left) increases the AD probability from ~ 0 to 0.4 when PRS is the lowest and from 0.6 to 0.76 when the PRS is highest (solid line vs dashed line). For TREM2 (right), these values are 0 to 0.13 (low PRS) and 0.6 to 0.66 (high PRS)