Fig. 1
From: Probability of Alzheimer’s disease based on common and rare genetic variants
Probability of Alzheimer’s disease, ignoring change in APOE-ε4 allele frequency due to age. ORS - Oligogenic Risk Score including SNPs with a p-value threshold pT ≤ 10-5. PRS - Polygenic Risk Score including SNPs with a p-value threshold pT ≤ 0.1. PRS.AD - PRS calculated as a weighted sum of PRS.no.APOE, including SNPs with a pT ≤ 0.1 excluding APOE region (CHR19:44.4-46.5), and APOE (ε2 + ε4), where APOE effects were weighted with effect sizes (B(ε2) = -0.47 and B(ε4) = 1.12) as in Kunkle et al. 2019 [2]