Fig. 5

Effect of TTR stabilization by IDIF in the thickness of the collagen IV layer and vessel length of AD/TTR+/− mice. A Representative images and quantification plots of collagen IV (red) levels in the BM of cortex and hippocampus vessels derived from 7-month-old AD mice AD/TTR+/- mice non-treated (n = 6), or treated with IDIF (IDIF treated, n = 6 for cortex; n = 9 for hippocampus), evidencing a significantly decreased collagen IV layer in treated mice. Scale bar = 5 μm. B Representative images and quantification plots of the length of brain vessels, as evaluated by collagen IV staining, from 7-month-old AD mice AD/TTR+/− non-treated (n = 7) or treated with IDIF (IDIF treated, n = 8) showing a significantly increased vessel length in the hippocampus of IDIF treated compared to non-treated mice. Scale bar = 50 μm. Data are expressed as mean ± SEM. *p < 0.05; ****p < 0.0001