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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Neuroprotection in early stages of Alzheimer’s disease is promoted by transthyretin angiogenic properties

Fig. 3

Quantification of angiogenesis-related proteins. Supernatants from hCMEC/D3 cells grown under conditions of tube formation were collected 9 h after incubation with media alone or with rec TTR (1 μM). A Ten of the most common angiogenesis-related proteins were quantified using bead-based LEGENDplex assay by flow cytometry. Rec TTR 1 μM revealed ability to significantly increase the levels of IL-6, IL-8, Ang-2, and VEGF. Comparisons are relative to the negative control. B IL-6 levels measured by ELISA showed that while TTR 10 nM did not affect IL-6, TTR concentrations 25 nM-1 μM increased, in a concentration-dependent manner, the levels of IL-6. Data are expressed as mean ± SEM. *p < 0.05; **p< 0.01; ***p < 0.001

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Alzheimer's Research & Therapy

ISSN: 1758-9193