Table 1 Subjects characteristics

Amyloid⁺ (n = 183)

CN (n = 93)

MCI (n = 60)

Dementia (n = 30)

p value

Age in years

75.67 (7.25)

76.16 (6.82)

76.95 (7.90)

0.692

Sex (male/female)

40/53

35/25

14/16

0.175

Years of education

16.59 (2.30)

15.78 (2.73)

16.1 (2.34)

0.132

MMSE score

28.83 (1.48)^b,c

27.2 (2.32)^a,c

22.27 (3.85)^a,b

 < 0.001

ADAS13 score

12.88 (5.27)^b,c

19.44 (6.92)^a,c

32.50 (9.32)^a,b

 < 0.001

ADNI-MEM score

0.95 (0.56)^b,c

0.13 (0.60)^a,c

 − 0.73 (0.73)^a,b

 < 0.001

Amyloid-PET CL

62.10 (32.54)^c

75.72 (37.44)

88.30 (36.61)^a

 < 0.001

Global Tau-PET SUVR

1.13 (0.09)^b,c

1.22 (0.18)^a,c

1.38 (0.36)^a,b

 < 0.001

Braak⁰/Braak^I+/Braak^I–IV+/Braak^I–VI+/Braak^atypical+

68/16/6/1/2

22/14/13/8/3

6/4/6/13/1

 < 0.001

Mean cognitive follow-up in years

2.03 (0.68)

1.88 (0.87)

1.67 (0.73)

0.072

Amyloid⁻ (n = 213)

CN (n = 146)

MCI (n = 62)

Dementia (n = 5)

p value

Age in years

72.76 (6.87) ^b

75.47 (8.60) ^a

71.22 (7.45)

0.045

Sex (female/male)

60/86

39/23

3/2

0.014

Years of education

16.95 (2.42)^c

16.18 (3.00)

14 (2.83)^a

0.011

MMSE score

29.21 (0.98)^b,c

28.56 (1.72)^a,c

24.4 (1.14)^a,b

 < 0.001

ADAS13 score

11.16 (4.29)^b,c

16.19 (5.43)^a,c

30.07 (4.39)^a,b

 < 0.001

ADNI-MEM score

1.10 (0.60)^b,c

0.60 (0.56)^a,c

 − 0.61 (0.59)^a,b

 < 0.001

Amyloid-PET CL

5.60 (8.82)^b

 − 0.72 (12.34)^a

 − 3.03 (8.87)

 < 0.001

Global Tau-PET SUVR

1.09 (0.07)

1.08 (0.08)

1.08 (0.07)

0.811

Braak⁰/Braak^I+/Braak^I–IV+/Braak^I–VI+/Braak^atypical+

137/5/1/2/1

56/4/1/0/1

4/1/0/0/0

0.718

Mean cognitive follow-up in years

2.18 (0.62)

2.01 (0.92)

1.53 (0.58)

0.056