|
Amyloid+ (n = 183)
|
CN (n = 93)
|
MCI (n = 60)
|
Dementia (n = 30)
|
p value
|
|
Age in years
|
75.67 (7.25)
|
76.16 (6.82)
|
76.95 (7.90)
|
0.692
|
|
Sex (male/female)
|
40/53
|
35/25
|
14/16
|
0.175
|
|
Years of education
|
16.59 (2.30)
|
15.78 (2.73)
|
16.1 (2.34)
|
0.132
|
|
MMSE score
|
28.83 (1.48)b,c
|
27.2 (2.32)a,c
|
22.27 (3.85)a,b
|
< 0.001
|
|
ADAS13 score
|
12.88 (5.27)b,c
|
19.44 (6.92)a,c
|
32.50 (9.32)a,b
|
< 0.001
|
|
ADNI-MEM score
|
0.95 (0.56)b,c
|
0.13 (0.60)a,c
|
− 0.73 (0.73)a,b
|
< 0.001
|
|
Amyloid-PET CL
|
62.10 (32.54)c
|
75.72 (37.44)
|
88.30 (36.61)a
|
< 0.001
|
|
Global Tau-PET SUVR
|
1.13 (0.09)b,c
|
1.22 (0.18)a,c
|
1.38 (0.36)a,b
|
< 0.001
|
|
Braak0/BraakI+/BraakI–IV+/BraakI–VI+/Braakatypical+
|
68/16/6/1/2
|
22/14/13/8/3
|
6/4/6/13/1
|
< 0.001
|
|
Mean cognitive follow-up in years
|
2.03 (0.68)
|
1.88 (0.87)
|
1.67 (0.73)
|
0.072
|
|
Amyloid− (n = 213)
|
CN (n = 146)
|
MCI (n = 62)
|
Dementia (n = 5)
|
p value
|
|
Age in years
|
72.76 (6.87) b
|
75.47 (8.60) a
|
71.22 (7.45)
|
0.045
|
|
Sex (female/male)
|
60/86
|
39/23
|
3/2
|
0.014
|
|
Years of education
|
16.95 (2.42)c
|
16.18 (3.00)
|
14 (2.83)a
|
0.011
|
|
MMSE score
|
29.21 (0.98)b,c
|
28.56 (1.72)a,c
|
24.4 (1.14)a,b
|
< 0.001
|
|
ADAS13 score
|
11.16 (4.29)b,c
|
16.19 (5.43)a,c
|
30.07 (4.39)a,b
|
< 0.001
|
|
ADNI-MEM score
|
1.10 (0.60)b,c
|
0.60 (0.56)a,c
|
− 0.61 (0.59)a,b
|
< 0.001
|
|
Amyloid-PET CL
|
5.60 (8.82)b
|
− 0.72 (12.34)a
|
− 3.03 (8.87)
|
< 0.001
|
|
Global Tau-PET SUVR
|
1.09 (0.07)
|
1.08 (0.08)
|
1.08 (0.07)
|
0.811
|
|
Braak0/BraakI+/BraakI–IV+/BraakI–VI+/Braakatypical+
|
137/5/1/2/1
|
56/4/1/0/1
|
4/1/0/0/0
|
0.718
|
|
Mean cognitive follow-up in years
|
2.18 (0.62)
|
2.01 (0.92)
|
1.53 (0.58)
|
0.056
|
- Values are presented as mean (SD)
- p values were derived from ANOVAs for continuous measures and from chi-squared tests for categorical measures
- MMSE Mini-Mental State Examination, ADAS13 Alzheimer’s disease assessment scale, cognitive subscale, ADNI-MEM episodic memory composite score
- Mean values significantly (p < 0.05, post hoc tests) different from aCN, bMCI, and cDementia
