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Table 1 Subjects characteristics

From: Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

Amyloid+ (n = 183) CN (n = 93) MCI (n = 60) Dementia (n = 30) p value
Age in years 75.67 (7.25) 76.16 (6.82) 76.95 (7.90) 0.692
Sex (male/female) 40/53 35/25 14/16 0.175
Years of education 16.59 (2.30) 15.78 (2.73) 16.1 (2.34) 0.132
MMSE score 28.83 (1.48)b,c 27.2 (2.32)a,c 22.27 (3.85)a,b  < 0.001
ADAS13 score 12.88 (5.27)b,c 19.44 (6.92)a,c 32.50 (9.32)a,b  < 0.001
ADNI-MEM score 0.95 (0.56)b,c 0.13 (0.60)a,c  − 0.73 (0.73)a,b  < 0.001
Amyloid-PET CL 62.10 (32.54)c 75.72 (37.44) 88.30 (36.61)a  < 0.001
Global Tau-PET SUVR 1.13 (0.09)b,c 1.22 (0.18)a,c 1.38 (0.36)a,b  < 0.001
Braak0/BraakI+/BraakI–IV+/BraakI–VI+/Braakatypical+ 68/16/6/1/2 22/14/13/8/3 6/4/6/13/1  < 0.001
Mean cognitive follow-up in years 2.03 (0.68) 1.88 (0.87) 1.67 (0.73) 0.072
Amyloid (n = 213) CN (n = 146) MCI (n = 62) Dementia (n = 5) p value
Age in years 72.76 (6.87) b 75.47 (8.60) a 71.22 (7.45) 0.045
Sex (female/male) 60/86 39/23 3/2 0.014
Years of education 16.95 (2.42)c 16.18 (3.00) 14 (2.83)a 0.011
MMSE score 29.21 (0.98)b,c 28.56 (1.72)a,c 24.4 (1.14)a,b  < 0.001
ADAS13 score 11.16 (4.29)b,c 16.19 (5.43)a,c 30.07 (4.39)a,b  < 0.001
ADNI-MEM score 1.10 (0.60)b,c 0.60 (0.56)a,c  − 0.61 (0.59)a,b  < 0.001
Amyloid-PET CL 5.60 (8.82)b  − 0.72 (12.34)a  − 3.03 (8.87)  < 0.001
Global Tau-PET SUVR 1.09 (0.07) 1.08 (0.08) 1.08 (0.07) 0.811
Braak0/BraakI+/BraakI–IV+/BraakI–VI+/Braakatypical+ 137/5/1/2/1 56/4/1/0/1 4/1/0/0/0 0.718
Mean cognitive follow-up in years 2.18 (0.62) 2.01 (0.92) 1.53 (0.58) 0.056
  1. Values are presented as mean (SD)
  2. p values were derived from ANOVAs for continuous measures and from chi-squared tests for categorical measures
  3. MMSE Mini-Mental State Examination, ADAS13 Alzheimer’s disease assessment scale, cognitive subscale, ADNI-MEM episodic memory composite score
  4. Mean values significantly (p < 0.05, post hoc tests) different from aCN, bMCI, and cDementia