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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

Fig. 2

Scatterplot illustrating the association between global tau-PET SUVRs, baseline global amyloid-PET (i.e., Centiloid), and annual cognitive changes of the Mini Mental State Examination (MMSE; A + B), Alzheimer’s Disease Assessment Scale Cognition 13-item scale (ADAS13; D + E), and ADNI-MEM (G + H). Standardized beta-values were derived from linear regression controlling for age, sex, education, clinical diagnosis, and the baseline score of the respective cognitive test. Bootstrapping analysis with 1000 iterations (C + F + I) revealed that bootstrapped distributions of partial R2 values (i.e., explained variance in cognitive changes) were higher for global tau-PET than for global amyloid-PET. Bonferroni correction applied, adjusted alpha level = 0.017; significant p-values are marked with *; uncorrected significant p values (p < 0.05) are marked with #. Note, that the association between amyloid-PET and ADNI-MEM did not survive Bonferroni correction

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