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Table. 3 Associations between enlargement of perivascular spaces in basal ganglia and centrum semiovale regions, and demographic and cardiovascular risk factors. Legend: n, count of individuals for each categorical variable; SD, standard deviation; BG, basal ganglia; CS, centrum semiovale; ePVS, enlarged perivascular spaces; WMH, white matter hyperintensities; GM, gray matter volume; TIV, total intracranial volume; OR, odds ratio; CI, confidence interval

From: Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum

  BG-ePVS CS-ePVS
  OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
  Degree 2 + 3 vs Degree 1 Degree 2 vs Degree 1 Degree 3 + 4 vs Degree 1 Degree 3 + 4 vs Degree 2
Sex, n (%)
  Male Ref Ref Ref Ref
  Female 1.29 [ 0.65, 3.04] 2.32 [0.88, 6.33] 5.5 [1.59, 21.06] 3.61 [1.39, 9.92]
  Age (years) 1.14 [1.07, 1.23] 1.1 [1.01, 1.20] 1.27 [1.13, 1.45] 1.16 [1.05, 1.28]
APOE-ε4 allele carriers, n(%)
  Non-carriers Ref Ref Ref Ref
  Heterozygous 1.07 [0.59, 2.19] 1.03 [0.49, 2.23] 0.86 [0.31, 2.41] 0.99 [ 0.45, 2.11]
  Homozygous 1.33 [0.50, 6.34] 0.57 [0.17, 2.01] 0.72 [0.10, 4.03] 5.03 [0.86, 31.43]
  Systolic blood pressure (mmHg) 1.02 [0.99, 1.01] 1.02 [0.98, 1.06]   
  Diastolic blood pressure (mmHg)    1.06 [1.004, 1.12] 1.02 [0.98, 1.06]
Physical activity, n (%)
  Non-active Ref Ref Ref Ref
  Active 0.52 [0.26, 1.27] 0.78 [ 0.31, 1.87] 0.48 [0.13, 1.69] 0.98 [0.41, 2.46]
  Total GM (mm3) 1.0001 [0.99, 1.001] 1.0001 [0.99, 1.001] 1.0001 [1.0001, 1.001] 1.0001 [0.99, 1.00001]
  WMH (ml) 1.17 [1.0001, 1.45] 1.07 [0.91, 1.31] 1.08 [0.82, 1.47] 1.001 [0.99,1.01]
  TIV (mm3) 1.0001 [0.99, 1.001] 0.999 [0.99, 1.001] 1.0001 [0.99, 1.00001] 1.0001 [0.99, 1.00001]