Table. 3 Associations between enlargement of perivascular spaces in basal ganglia and centrum semiovale regions, and demographic and cardiovascular risk factors. Legend: n, count of individuals for each categorical variable; SD, standard deviation; BG, basal ganglia; CS, centrum semiovale; ePVS, enlarged perivascular spaces; WMH, white matter hyperintensities; GM, gray matter volume; TIV, total intracranial volume; OR, odds ratio; CI, confidence interval
BG-ePVS | CS-ePVS | |||
|---|---|---|---|---|
OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
Degree 2 + 3 vs Degree 1 | Degree 2 vs Degree 1 | Degree 3 + 4 vs Degree 1 | Degree 3 + 4 vs Degree 2 | |
Sex, n (%) | ||||
Male | Ref | Ref | Ref | Ref |
Female | 1.29 [ 0.65, 3.04] | 2.32 [0.88, 6.33] | 5.5 [1.59, 21.06] | 3.61 [1.39, 9.92] |
Age (years) | 1.14 [1.07, 1.23] | 1.1 [1.01, 1.20] | 1.27 [1.13, 1.45] | 1.16 [1.05, 1.28] |
APOE-ε4 allele carriers, n(%) | ||||
Non-carriers | Ref | Ref | Ref | Ref |
Heterozygous | 1.07 [0.59, 2.19] | 1.03 [0.49, 2.23] | 0.86 [0.31, 2.41] | 0.99 [ 0.45, 2.11] |
Homozygous | 1.33 [0.50, 6.34] | 0.57 [0.17, 2.01] | 0.72 [0.10, 4.03] | 5.03 [0.86, 31.43] |
Systolic blood pressure (mmHg) | 1.02 [0.99, 1.01] | 1.02 [0.98, 1.06] | ||
Diastolic blood pressure (mmHg) | 1.06 [1.004, 1.12] | 1.02 [0.98, 1.06] | ||
Physical activity, n (%) | ||||
Non-active | Ref | Ref | Ref | Ref |
Active | 0.52 [0.26, 1.27] | 0.78 [ 0.31, 1.87] | 0.48 [0.13, 1.69] | 0.98 [0.41, 2.46] |
Total GM (mm3) | 1.0001 [0.99, 1.001] | 1.0001 [0.99, 1.001] | 1.0001 [1.0001, 1.001] | 1.0001 [0.99, 1.00001] |
WMH (ml) | 1.17 [1.0001, 1.45] | 1.07 [0.91, 1.31] | 1.08 [0.82, 1.47] | 1.001 [0.99,1.01] |
TIV (mm3) | 1.0001 [0.99, 1.001] | 0.999 [0.99, 1.001] | 1.0001 [0.99, 1.00001] | 1.0001 [0.99, 1.00001] |