Table. 2 Characteristics of the sample of CSF biomarkers across degrees of perivascular spaces. Legend: N, sample size; n, count of individuals for each categorical variable; SD, standard deviation; BG, basal ganglia; CS, centrum semiovale; ePVS, enlarged perivascular spaces
BG-ePVS | CS-ePVS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
N | Mean (SD) | Degree 1 (n = 162) | Degree 2 + Degree 3 (n = 160) | p value | Degree 1 (n = 90) | Degree 2 (n = 147) | Degree 3 + 4 (n = 85) | p value | |
Aβ42 (pg/mL) | 322 | 1374 (604) | 1287 (520) | 1462 (669) | 0.009 | 1321 (637) | 1392 (538) | 1399 (677) | 0.616 |
Aβ40 | 322 | 17.9 (4.94) | 16.8 (4.32) | 19.0 (5.28) | < 0.001 | 16.5 (4.43) | 17.9 (4.55) | 19.3 (5.71) | 0.001 |
Aβ42/40 cat, n (%) | 322 | 0.102 | 0.121 | ||||||
Negative | 200 (62.1%) | 93 (57.4%) | 107 (66.9%) | 50 (55.6%) | 100 (68.0%) | 50 (58.8%) | |||
Positive | 122 (37.9%) | 69 (42.6%) | 53 (33.1%) | 40 (44.4%) | 47 (32.0%) | 35 (41.2%) | |||
p-Tau (pg/mL) | 312 | 16.8 (7.67) | 15.4 (6.08) | 18.2 (8.77) | 0.001 | 15.1 (5.70) | 16.4 (6.60) | 19.1 (10.2) | 0.002 |
t-Tau (pg/mL) | 322 | 202 (73.6) | 186 (61.6) | 217 (81.4) | < 0.001 | 184 (61.5) | 198 (66.1) | 227 (90.1) | < 0.001 |
GFAP (pg/mL) | 322 | 7.66 (2.72) | 7.46 (3.00) | 7.87 (2.39) | 0.167 | 7.22 (2.13) | 7.43 (2.55) | 8.54 (3.32) | 0.002 |
YKL40 (pg/mL) | 322 | 150 (55.3) | 136 (45.7) | 165 (60.3) | < 0.001 | 139 (52.6) | 145 (46.1) | 171 (66.7) | < 0.001 |
TREM2 (pg/mL) | 322 | 8.04 (2.28) | 7.55 (2.02) | 8.54 (2.41) | < 0.001 | 7.73 (2.22) | 7.85 (2.18) | 8.69 (2.38) | 0.008 |
IL6 (pg/mL) | 322 | 4.08 (2.04) | 4.20 (2.16) | 3.97 (1.90) | 0.311 | 4.12 (1.92) | 4.08 (2.35) | 4.03 (1.55) | 0.960 |
NFL (pg/mL) | 322 | 83.4 (36.7) | 78.8 (27.7) | 88.1 (43.6) | 0.024 | 82.5 (48.4) | 79.8 (25.5) | 90.6 (38.2) | 0.093 |
Neurogranin (pg/mL) | 322 | 816 (339) | 740 (299) | 893 (359) | < 0.001 | 716 (301) | 809 (306) | 933 (394) | < 0.001 |
S100 (pg/mL) | 322 | 1.02 (0.24) | 1.02 (0.25) | 1.03 (0.23) | 0.722 | 0.99 (0.22) | 1.01 (0.21) | 1.07 (0.29) | 0.080 |
α-Synuclein (pg/mL) | 322 | 245 (277) | 212 (180) | 278 (347) | 0.035 | 199 (147) | 249 (265) | 286 (381) | 0.108 |