Skip to main content

Table. 2 Characteristics of the sample of CSF biomarkers across degrees of perivascular spaces. Legend: N, sample size; n, count of individuals for each categorical variable; SD, standard deviation; BG, basal ganglia; CS, centrum semiovale; ePVS, enlarged perivascular spaces

From: Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum

   BG-ePVS CS-ePVS
  N Mean (SD) Degree 1 (n = 162) Degree 2 + Degree 3 (n = 160) p value Degree 1 (n = 90) Degree 2 (n = 147) Degree 3 + 4 (n = 85) p value
Aβ42 (pg/mL) 322 1374 (604) 1287 (520) 1462 (669) 0.009 1321 (637) 1392 (538) 1399 (677) 0.616
Aβ40 322 17.9 (4.94) 16.8 (4.32) 19.0 (5.28)  < 0.001 16.5 (4.43) 17.9 (4.55) 19.3 (5.71) 0.001
Aβ42/40 cat, n (%) 322     0.102     0.121
Negative   200 (62.1%) 93 (57.4%) 107 (66.9%)   50 (55.6%) 100 (68.0%) 50 (58.8%)  
Positive   122 (37.9%) 69 (42.6%) 53 (33.1%)   40 (44.4%) 47 (32.0%) 35 (41.2%)  
p-Tau (pg/mL) 312 16.8 (7.67) 15.4 (6.08) 18.2 (8.77) 0.001 15.1 (5.70) 16.4 (6.60) 19.1 (10.2) 0.002
t-Tau (pg/mL) 322 202 (73.6) 186 (61.6) 217 (81.4)  < 0.001 184 (61.5) 198 (66.1) 227 (90.1)  < 0.001
GFAP (pg/mL) 322 7.66 (2.72) 7.46 (3.00) 7.87 (2.39) 0.167 7.22 (2.13) 7.43 (2.55) 8.54 (3.32) 0.002
YKL40 (pg/mL) 322 150 (55.3) 136 (45.7) 165 (60.3)  < 0.001 139 (52.6) 145 (46.1) 171 (66.7)  < 0.001
TREM2 (pg/mL) 322 8.04 (2.28) 7.55 (2.02) 8.54 (2.41)  < 0.001 7.73 (2.22) 7.85 (2.18) 8.69 (2.38) 0.008
IL6 (pg/mL) 322 4.08 (2.04) 4.20 (2.16) 3.97 (1.90) 0.311 4.12 (1.92) 4.08 (2.35) 4.03 (1.55) 0.960
NFL (pg/mL) 322 83.4 (36.7) 78.8 (27.7) 88.1 (43.6) 0.024 82.5 (48.4) 79.8 (25.5) 90.6 (38.2) 0.093
Neurogranin (pg/mL) 322 816 (339) 740 (299) 893 (359)  < 0.001 716 (301) 809 (306) 933 (394)  < 0.001
S100 (pg/mL) 322 1.02 (0.24) 1.02 (0.25) 1.03 (0.23) 0.722 0.99 (0.22) 1.01 (0.21) 1.07 (0.29) 0.080
α-Synuclein (pg/mL) 322 245 (277) 212 (180) 278 (347) 0.035 199 (147) 249 (265) 286 (381) 0.108