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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum

Fig. 3

Distribution of Perivascular Spaces by degree of severity. Legend: BG, Basal Ganglia; CS, centrum semiovale. Model 1 shows associations correcting by age, sex and cardiovascular risk factors. Model 2 shows associations correcting by age, sex, cardiovascular risk factors and Aβ40. Blue color intensities indicate the magnitude of the associations (higher levels of biomarkers). Abbreviations: AD, Alzheimer’s disease; PVS, perivascular spaces; BG, basal ganglia; CS, centrum semiovale; CSF, cerebrospinal fluid; Aβ40, amyloid-β 40; Aβ42, amyloid-β 42; GFAP, glial fibrillary acidic protein; IL6, interleukin-6; NfL, neurofilament light; p-tau, phosphorylated tau; sTREM2, soluble triggering receptor expressed on myeloid cells 2 (TREM2); t-tau, total tau

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Alzheimer's Research & Therapy

ISSN: 1758-9193