Combination of white matter hyperintensities and Aβ burden is related to cognitive composites domain scores in subjective cognitive decline: the FACEHBI cohort

Table 1 Association between CCs domain scores, WMHs, and SUVR

CCs (dependent variable)	Fazekas			ARWMC			FreeSurfer			SUVR
CCs (dependent variable)	B	95% CI	p	B	95% CI	p	B	95% CI	p	B	95% CI	p
EF-FL	.030	(− .251, .312)	.832	− .065	(− .450, .320)	.739	− .092	(− .723, .539)	.774	.438	(− .458, 1.334)	.337
EF-PS	− .007	(− .266, .252)	.956	.043	(− .313, .399)	.812	.204	(− .375, .783)	.489	.615	(− .208, 1.438)	.142
EF-AT	.250	(− .027, .528)	.077	.464	(.080, .848)	.018	.142	(− .49, − .777)	.659	− .549	(− 1.450, .351)	.230
FN-AM	− .173	(− .465, .119)	.244	− .164	(− .564, .235)	.418	− 1.034	(− .1.676, − .393)	.002*	− 1.216	(− 2.140, − .292)	.010
FO-AM	− .364	(− .651, − .077)	.013	− .392	(− .789, .004)	.056	− .862	(− 1.503, .222)	.009	− .250	(− 1.176, .677)	.596
VR-M	− .097	(− .395, .200)	.519	.088	(− .317, .494)	.668	− .070	(− .737, .598)	.837	− .415	(− 1.367, .536)	.390
VI-M	.346	(− .159, .452)	.346	.035	(− .389, .459)	.872	− .098	(− .787 − .592)	.837	− 1.313	(− 2.272, − .355)	.008
Language	.035	(− .252, .322)	.809	− .004	(− .398, .390)	.984	− .413	(− 1.051, .226)	.204	− .467	(− 1.380, .446)	.314

CCs Cognitive Composites domain scores, EF-FL Executive Function-Fluencies, EF-PS Executive Function Processing Speed, EF-AT Executive Function Attention, FN-AM Face–Name Associative Memory, FO-AM Face–Occupations Associative Memory, VR-M Verbal Memory, VI-M Visual Memory, SUVR Standardized uptake value ratio, CI Confidence Interval
Age, years of education, sex, and APOE e4 (none vs. one or more alleles e4) were used as adjusting variables. Multiple linear regression analysis between each CCs domain score, Fazekas, ARWMC, FreeSurfer, and SUVR was used; ^*Adjusted p value < .05 after correction for multiple tests (Hommel’s method)

ISSN: 1758-9193