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Table 2 Summary of global network measures

From: Tau-related grey matter network breakdown across the Alzheimer’s disease continuum

 

Control

n = 178

Preclinical AD

n = 105

Prodromal AD

n = 122

AD dementia

n =128

Network size

7171.15 (671.92)d

7007.46 (672.18)d

6987.52 (612.17)d

6666.01 (581.66)a, b, c

Degree

1193.11 (148.21) d

1159.10 (139.57)d

1140.61 (133.61)d

1072.01 (138.78)a, b, c

Connectivity density

16.61 (0.98)

16.53 (1.07)

16.30 (0.92)

16.06 (1.27)

Clustering coefficient

0.46 (0.02)c, d

0.46 (0.02)c, d

0.45 (0.02)a, b, d

0.44 (0.02)a, b, c

Path length

1.98 (0.03)c, d

1.97 (0.03)c, d

1.96 (0.03)a, b, d

1.96 (0.03)a, b, c

Gamma

1.58 (0.11)c, d

1.54 (0.12)c, d

1.50 (0.09)a, b, d

1.43 (0.09)a, b, c

Lambda

1.08 (0.01)c, d

1.08 (0.02)c, d

1.07 (0.01)a, b, d

1.06 (0.01)a, b, c

Small world coefficient

1.47 (0.08)c, d

1.43 (0.09)c, d

1.40 (0.07)a, b, d

1.35 (0.07)a, b, c

  1. Data are presented as mean ± SD; AD Alzheimer’s disease; gamma is normalised clustering; lambda is normalised path length; asignificantly different than control; bsignificantly different than preclinical AD; csignificantly different than prodromal AD; dsignificantly different than AD dementia at p < 0.05 when adjusting for age, sex, TIV, and connectivity density (clustering, path length, γ, λ, small world-only)