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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Tau-related grey matter network breakdown across the Alzheimer’s disease continuum

Fig. 3

MMSE and ADAS-Cog delayed recall performance in relation to Tau-PET and Small world coefficient. Scatterplot showing the association of tau-PET SUVR values in the temporal meta-ROI and standardised grey matter network small world values with MMSE scores (top), and the ADAS-Cog delayed recall (bottom). Mediation analysis showing how small world topology mediates the effect of tau pathology on cognitive performance (right). Regression coefficients with a 95% confidence interval are displayed. a The effect of tau load on small world topology. b The effect of small world topology on cognitive performance when controlling for tau. c The total effect of tau on cognition (without controlling for mediation effects). c’ The direct effect of tau pathology on cognition when adjusting for mediation. cc’, The mediation effect. *p < 0.05

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