Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services—part 4 of 6

Table 4 Dementia risk scores used as surrogate outcomes in multidomain prevention trials

Study	Trial	Dementia risk score	Outcome type	Main results
O’Donnell et al., 2015 [39]	In-MINDD	LIBRA	Primary	Participants in both arms of the trial showed a small improvement in their LIBRA score. The improvement was slightly larger in the intervention arm, but not statistically significant after 6 months.
Solomon et al., 2018 [40]	FINGER	CAIDE	Post hoc	The intervention had a significant impact on lowering the CAIDE risk score after 2 years.
Barbera et al., 2020 [41]	FINGER MAPT preDIVA	CAIDE	Post hoc, individual participants pooled analysis	CAIDE score decreased significantly as a result of the interventions after 2 years.
Coley et al., 2020 [42]	preDIVA MAPT HATICE	LIBRA and CAIDE	Post hoc, each trial analyzed separately	CAIDE and LIBRA scores showed statistically significant between-group differences after multidomain interventions after 1.5 to 2 years.
Deckers et al., 2020 [29]	FINGER	LIBRA	Post hoc	The intervention decreased dementia risk as indicated by decreasing LIBRA score after 2 years.
McMaster et al., 2020 [23]	Body Brain Life	ANU-ADRI	Primary	Significant reduction in ANU-ADRI score for BBL compared with control after 2 months.

ANU-ADRI Australian National - University Alzheimer’s Disease Risk Index, CAIDE Cardiovascular Risk Factors, Aging and Dementia, FINGER Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, HATICE Healthy Ageing Through Internet Counselling in the Elderly, In-MINDD Innovative Midlife Intervention for Dementia Deterrence, LIBRA LIfestyle for BRAin health, MAPT Multidomain Alzheimer Preventive Trial, preDIVA Prevention of Dementia by Intensive Vascular Care

ISSN: 1758-9193