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Table 4 Dementia risk scores used as surrogate outcomes in multidomain prevention trials

From: Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services—part 4 of 6

Study Trial Dementia risk score Outcome type Main results
O’Donnell et al., 2015 [39] In-MINDD LIBRA Primary Participants in both arms of the trial showed a small improvement in their LIBRA score. The improvement was slightly larger in the intervention arm, but not statistically significant after 6 months.
Solomon et al., 2018 [40] FINGER CAIDE Post hoc The intervention had a significant impact on lowering the CAIDE risk score after 2 years.
Barbera et al., 2020 [41] FINGER
MAPT
preDIVA
CAIDE Post hoc, individual participants pooled analysis CAIDE score decreased significantly as a result of the interventions after 2 years.
Coley et al., 2020 [42] preDIVA
MAPT
HATICE
LIBRA and CAIDE Post hoc, each trial analyzed separately CAIDE and LIBRA scores showed statistically significant between-group differences after multidomain interventions after 1.5 to 2 years.
Deckers et al., 2020 [29] FINGER LIBRA Post hoc The intervention decreased dementia risk as indicated by decreasing LIBRA score after 2 years.
McMaster et al., 2020 [23] Body Brain Life ANU-ADRI Primary Significant reduction in ANU-ADRI score for BBL compared with control after 2 months.
  1. ANU-ADRI Australian National - University Alzheimer’s Disease Risk Index, CAIDE Cardiovascular Risk Factors, Aging and Dementia, FINGER Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability, HATICE Healthy Ageing Through Internet Counselling in the Elderly, In-MINDD Innovative Midlife Intervention for Dementia Deterrence, LIBRA LIfestyle for BRAin health, MAPT Multidomain Alzheimer Preventive Trial, preDIVA Prevention of Dementia by Intensive Vascular Care