From: Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers
Alzheimer’s disease (n = 149) | Vascular dementia (n = 96) | Death (n = 465) | |
---|---|---|---|
Short rLTL | 3.24 (1.404–7.462); P = 0.005 | 1.09 (0.668–1.780); P = 0.72 | 1.82 (1.234–2.682); P = 0.002 |
Long rLTL | 1.42 (0.751–2.697); P = 0.28 | 1.27 (0.758–2.120); P = 0.37 | 0.82 (0.637–1.056); P = 0.12 |
APOE ε4-carriers | 6.61 (3.592–12.168); P < 0.0001 | 1.28 (0.841–1.960); P = 0.26 | 0.70 (0.556–0.882); P = 0.002 |
Short rLTL/APOE ε4 interaction | 0.41 (0.181–0.920); P = 0.03 | – | – |
Long rLTL/APOE ε4 interaction | 0.40 (0.169–0.948); P = 0.03 | – | – |
High cholesterol (≥ 240 mg/dL) | 1.62 (1.061–2.463); P = 0.02 | 1.15 (0.736–1.830); P = 0.55 | 1.82 (1.234–2.682); P = 0.002 |
Pulse pressure, mmHg | 0.99 (0.986–1.006); P = 0.47 | 1.02 (1.005–1.030); P = 0.005 | 0.82 (0.637–1.056); P = 0.12 |
Plasma glucose, mg/dL | 0.99 (0.980–1.000); P = 0.04 | 1.00 (0.994–1.010); P = 0.97 | 0.70 (0.556–0.882); P = 0.002 |
Sedimentation rate, mm/h | 0.99 (0.984–1.014); P = 0.89 | 1.03 (0.977–1.040); P = 0.03 | 1.03 (1.017–1.042); P < 0.0001 |
Lymphocyte proportion | 0.002 (0.00004–0.156); P = 0.004 | 0.19 (0.012–2.870); P = 0.25 | 0.58 (0.166–2.057); P = 0.40 |
Gender, male | 0.37 (0.249–0.552); P < 0.0001 | 2.35 (0.666–3.600); P = 0.03 | 1.87 (1.531–2.274); P < 0.0001 |
Age at baseline, years | 2.29 (1.719–3.051); P < 0.0001 | 3.64 (2.571–23.640); P < 0.0001 | 1.21 (1.087–1.345); P = 0.0004 |
Age squared | 0.995 (0.992–0.997); P < 0.0001 | 0.991 (0.981–0.990); P < 0.0001 | 0.999 (0.998–1.000); P = 0.04 |
Short rLTL time interaction | 0.92 (0.869–0.972); P = 0.003 | – | 0.95 (0.922–0.983); P = 0.002 |
Sedimentation rate time interaction | – | 0.996 (0.995–1.000); P = 0.006 | 0.998 (0.997–0.999); P = 0.005 |
Lymphocyte proportion time interaction | 1.76 (1.266–2.447); P = 0.0007 | – | – |
Gender time interaction | – | 0.92 (0.850–0.986); P = 0.02 | – |
Pseudo likelihood ratio = 241 | Pseudo likelihood ratio = 123 | Pseudo likelihood ratio = 480 |