White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Desmarais, Philippe; Gao, Andrew F.; Lanctôt, Krista; Rogaeva, Ekaterina; Ramirez, Joel; Herrmann, Nathan; Stuss, Donald T.; Black, Sandra E.; Keith, Julia; Masellis, Mario

doi:10.1186/s13195-021-00869-6

Alzheimer's Research & Therapy

Table 4 Linear regression between white matter hyperintensities and neuropsychiatric symptoms across all subgroups

From: White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Neuropsychiatric symptom	Aberrant motor			Irritability			Night-time behaviors			Appetite/eating habit changes
Region	β coefficient	Unadjusted P value	FDR q value	β coefficient	Unadjusted P value	FDR q value	β coefficient	Unadjusted P value	FDR q value	β coefficient	Unadjusted P value	FDR q value
Total	0.136	0.277	0.046	0.062	0.593	0.092	0.149	0.239	0.031	0.075	0.539	0.077
Deep matter	0.070	0.566	0.092	0.136	0.223	0.046	0.306*	0.011*	0.015	0.071	0.546	0.085
Periventricular	0.138	0.275	0.031	0.047	0.687	0.092	0.116	0.363	0.046	0.070	0.564	0.077
Frontal	0.241	0.052	0.046	−0.013	0.913	0.092	0.322*	0.010*	0.023	0.237	0.049	0.038
Left	0.194	0.117	0.054	−0.085	0.471	0.092	0.267	0.029	0.015	0.198	0.093	0.046
Right	0.241	0.055	0.031	0.020	0.869	0.100	0.317	0.012	0.008	0.170	0.134	0.046
Frontal—medial	0.114	0.403	0.031	0.044	0.729	0.077	0.154	0.261	0.015	0.096	0.464	0.038
Left	−0.051	0.708	0.054	−0.003	0.979	0.092	0.215	0.113	0.015	−0.002	0.990	0.100
Right	0.178	0.168	0.015	0.016	0.893	0.092	0.092	0.483	0.054	0.150	0.188	0.023
Frontal—lateral	0.225	0.087	0.038	−0.060	0.628	0.100	0.313*	0.017*	0.023	0.196	0.122	0.054
Left	0.202	0.127	0.038	−0.101	0.428	0.077	0.186	0.154	0.054	0.169	0.186	0.062
Right	0.228	0.093	0.038	0.035	0.790	0.092	0.390*	0.003*	0.015	0.141	0.253	0.077
Temporal	0.128	0.292	0.031	0.110	0.327	0.038	−0.014	0.907	0.100	−0.034	0.770	0.077
Left	−0.011	0.925	0.100	−0.028	0.802	0.085	−0.066	0.585	0.054	−0.100	0.404	0.015
Right	0.192	0.112	0.038	0.193	0.087	0.023	0.036	0.770	0.085	0.032	0.789	0.092
Parietal	0.026	0.833	0.092	0.079	0.487	0.031	0.068	0.586	0.054	−0.023	0.846	0.100
Left	0.099	0.419	0.038	0.003	0.982	0.100	0.043	0.722	0.077	−0.029	0.810	0.092
Right	−0.020	0.873	0.077	0.138	0.226	0.023	0.120	0.341	0.038	0.012	0.921	0.085
Occipital	−0.022	0.857	0.092	0.146	0.189	0.015	−0.094	0.442	0.038	−0.139	0.232	0.023
Left	0.063	0.602	0.046	0.034	0.769	0.085	−0.050	0.683	0.062	−0.095	0.425	0.023
Right	−0.018	0.882	0.092	0.197	0.079	0.015	−0.058	0.635	0.046	−0.111	0.353	0.023

Associations between regional white matter hyperintensity volumes and neuropsychiatric symptoms were assessed using linear regression analyses. Estimates are presented as standardized β values to allow for comparison of effect sizes. Model: age, sex, vascular risk factors, and corresponding regional grey matter atrophy as covariates
*Significant result following Benjamini-Hochberg FDR correction for all correlational tests
Abbreviations: FDR false discovery rate, NPI Neuropsychiatric Inventory

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