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Table 4 Linear regression between white matter hyperintensities and neuropsychiatric symptoms across all subgroups

From: White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Neuropsychiatric symptom Aberrant motor Irritability Night-time behaviors Appetite/eating habit changes
Region β
coefficient
Unadjusted P value FDR
q value
β
coefficient
Unadjusted P value FDR
q value
β
coefficient
Unadjusted P value FDR
q value
β
coefficient
Unadjusted P value FDR
q value
Total 0.136 0.277 0.046 0.062 0.593 0.092 0.149 0.239 0.031 0.075 0.539 0.077
Deep matter 0.070 0.566 0.092 0.136 0.223 0.046 0.306* 0.011* 0.015 0.071 0.546 0.085
Periventricular 0.138 0.275 0.031 0.047 0.687 0.092 0.116 0.363 0.046 0.070 0.564 0.077
Frontal 0.241 0.052 0.046 −0.013 0.913 0.092 0.322* 0.010* 0.023 0.237 0.049 0.038
 Left 0.194 0.117 0.054 −0.085 0.471 0.092 0.267 0.029 0.015 0.198 0.093 0.046
 Right 0.241 0.055 0.031 0.020 0.869 0.100 0.317 0.012 0.008 0.170 0.134 0.046
Frontal—medial 0.114 0.403 0.031 0.044 0.729 0.077 0.154 0.261 0.015 0.096 0.464 0.038
 Left −0.051 0.708 0.054 −0.003 0.979 0.092 0.215 0.113 0.015 −0.002 0.990 0.100
 Right 0.178 0.168 0.015 0.016 0.893 0.092 0.092 0.483 0.054 0.150 0.188 0.023
Frontal—lateral 0.225 0.087 0.038 −0.060 0.628 0.100 0.313* 0.017* 0.023 0.196 0.122 0.054
 Left 0.202 0.127 0.038 −0.101 0.428 0.077 0.186 0.154 0.054 0.169 0.186 0.062
 Right 0.228 0.093 0.038 0.035 0.790 0.092 0.390* 0.003* 0.015 0.141 0.253 0.077
Temporal 0.128 0.292 0.031 0.110 0.327 0.038 −0.014 0.907 0.100 −0.034 0.770 0.077
 Left −0.011 0.925 0.100 −0.028 0.802 0.085 −0.066 0.585 0.054 −0.100 0.404 0.015
 Right 0.192 0.112 0.038 0.193 0.087 0.023 0.036 0.770 0.085 0.032 0.789 0.092
Parietal 0.026 0.833 0.092 0.079 0.487 0.031 0.068 0.586 0.054 −0.023 0.846 0.100
 Left 0.099 0.419 0.038 0.003 0.982 0.100 0.043 0.722 0.077 −0.029 0.810 0.092
 Right −0.020 0.873 0.077 0.138 0.226 0.023 0.120 0.341 0.038 0.012 0.921 0.085
Occipital −0.022 0.857 0.092 0.146 0.189 0.015 −0.094 0.442 0.038 −0.139 0.232 0.023
 Left 0.063 0.602 0.046 0.034 0.769 0.085 −0.050 0.683 0.062 −0.095 0.425 0.023
 Right −0.018 0.882 0.092 0.197 0.079 0.015 −0.058 0.635 0.046 −0.111 0.353 0.023
  1. Associations between regional white matter hyperintensity volumes and neuropsychiatric symptoms were assessed using linear regression analyses. Estimates are presented as standardized β values to allow for comparison of effect sizes. Model: age, sex, vascular risk factors, and corresponding regional grey matter atrophy as covariates
  2. *Significant result following Benjamini-Hochberg FDR correction for all correlational tests
  3. Abbreviations: FDR false discovery rate, NPI Neuropsychiatric Inventory