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Table 3 Linear regression between white matter hyperintensities and neuropsychiatric symptoms across all subgroups

From: White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Neuropsychiatric symptom Anxiety Euphoria Apathy Disinhibition
Region β
coefficient
Unadjusted P-value FDR
q-value
β
coefficient
Unadjusted P-value FDR
q-value
β
coefficient
Unadjusted P-value FDR
q-value
β
coefficient
Unadjusted P-value FDR
q-value
Total 0.056 0.653 0.100 0.109 0.373 0.062 0.256 0.033 0.015 0.105 0.401 0.069
Deep matter 0.119 0.321 0.054 0.317* 0.006* 0.008 0.088 0.453 0.069 0.189 0.118 0.031
Periventricular 0.043 0.731 0.100 0.071 0.582 0.085 0.265 0.028 0.015 0.086 0.494 0.069
Frontal 0.142 0.254 0.077 0.244 0.045 0.031 0.311* 0.009* 0.008 0.181 0.150 0.062
 Left 0.117 0.346 0.077 0.236 0.051 0.038 0.299 0.013 0.008 0.136 0.276 0.062
 Right 0.129 0.303 0.077 0.191 0.120 0.038 0.234 0.051 0.023 0.173 0.174 0.054
Frontal – medial −0.008 0.951 0.100 0.232 0.081 0.008 0.041 0.752 0.085 0.059 0.669 0.062
 Left −0.153 0.253 0.023 0.287 0.027 0.008 0.077 0.561 0.038 0.029 0.829 0.062
 Right 0.082 0.519 0.069 0.177 0.158 0.008 −0.011 0.929 0.100 0.085 0.510 0.062
Frontal – lateral 0.176 0.176 0.062 0.208 0.109 0.046 0.308* 0.013* 0.015 0.161 0.230 0.069
 Left 0.193 0.146 0.046 0.217 0.099 0.031 0.279 0.032 0.008 0.119 0.377 0.069
 Right 0.172 0.200 0.069 0.192 0.153 0.054 0.315* 0.013* 0.023 0.195 0.158 0.062
Temporal 0.095 0.426 0.054 −0.155 0.191 0.015 0.129 0.273 0.023 −0.030 0.806 0.092
 Left −0.084 0.483 0.031 −0.075 0.516 0.046 −0.047 0.695 0.069 −0.079 0.511 0.038
 Right 0.184 0.122 0.046 −0.135 0.253 0.062 0.229 0.053 0.015 0.027 0.825 0.100
Parietal −0.050 0.679 0.062 0.048 0.695 0.069 0.189 0.112 0.015 0.046 0.711 0.077
 Left −0.038 0.728 0.085 0.044 0.713 0.069 0.170 0.161 0.008 0.114 0.351 0.031
 Right −0.070 0.563 0.054 0.097 0.433 0.046 0.191 0.111 0.015 0.009 0.942 0.092
Occipital −0.050 0.675 0.062 −0.094 0.425 0.031 0.065 0.581 0.046 −0.024 0.843 0.077
 Left −0.025 0.835 0.092 −0.110 0.358 0.015 0.069 0.571 0.038 0.078 0.524 0.031
 Right −0.045 0.709 0.069 −0.056 0.643 0.054 0.112 0.358 0.031 −0.051 0.680 0.062
  1. Associations between regional white matter hyperintensity volumes and neuropsychiatric symptoms were assessed using linear regression analyses. Estimates are presented as standardized β values to allow for comparison of effect sizes. Model: age, sex, vascular risk factors, and corresponding regional grey matter atrophy as covariates
  2. *Significant result following Benjamini-Hochberg FDR correction for all correlational tests
  3. Abbreviations: FDR false discovery rate, NPI Neuropsychiatric Inventory