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Table 3 Linear regression between white matter hyperintensities and neuropsychiatric symptoms across all subgroups

From: White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Neuropsychiatric symptom

Anxiety

Euphoria

Apathy

Disinhibition

Region

β

coefficient

Unadjusted P-value

FDR

q-value

β

coefficient

Unadjusted P-value

FDR

q-value

β

coefficient

Unadjusted P-value

FDR

q-value

β

coefficient

Unadjusted P-value

FDR

q-value

Total

0.056

0.653

0.100

0.109

0.373

0.062

0.256

0.033

0.015

0.105

0.401

0.069

Deep matter

0.119

0.321

0.054

0.317*

0.006*

0.008

0.088

0.453

0.069

0.189

0.118

0.031

Periventricular

0.043

0.731

0.100

0.071

0.582

0.085

0.265

0.028

0.015

0.086

0.494

0.069

Frontal

0.142

0.254

0.077

0.244

0.045

0.031

0.311*

0.009*

0.008

0.181

0.150

0.062

 Left

0.117

0.346

0.077

0.236

0.051

0.038

0.299

0.013

0.008

0.136

0.276

0.062

 Right

0.129

0.303

0.077

0.191

0.120

0.038

0.234

0.051

0.023

0.173

0.174

0.054

Frontal – medial

−0.008

0.951

0.100

0.232

0.081

0.008

0.041

0.752

0.085

0.059

0.669

0.062

 Left

−0.153

0.253

0.023

0.287

0.027

0.008

0.077

0.561

0.038

0.029

0.829

0.062

 Right

0.082

0.519

0.069

0.177

0.158

0.008

−0.011

0.929

0.100

0.085

0.510

0.062

Frontal – lateral

0.176

0.176

0.062

0.208

0.109

0.046

0.308*

0.013*

0.015

0.161

0.230

0.069

 Left

0.193

0.146

0.046

0.217

0.099

0.031

0.279

0.032

0.008

0.119

0.377

0.069

 Right

0.172

0.200

0.069

0.192

0.153

0.054

0.315*

0.013*

0.023

0.195

0.158

0.062

Temporal

0.095

0.426

0.054

−0.155

0.191

0.015

0.129

0.273

0.023

−0.030

0.806

0.092

 Left

−0.084

0.483

0.031

−0.075

0.516

0.046

−0.047

0.695

0.069

−0.079

0.511

0.038

 Right

0.184

0.122

0.046

−0.135

0.253

0.062

0.229

0.053

0.015

0.027

0.825

0.100

Parietal

−0.050

0.679

0.062

0.048

0.695

0.069

0.189

0.112

0.015

0.046

0.711

0.077

 Left

−0.038

0.728

0.085

0.044

0.713

0.069

0.170

0.161

0.008

0.114

0.351

0.031

 Right

−0.070

0.563

0.054

0.097

0.433

0.046

0.191

0.111

0.015

0.009

0.942

0.092

Occipital

−0.050

0.675

0.062

−0.094

0.425

0.031

0.065

0.581

0.046

−0.024

0.843

0.077

 Left

−0.025

0.835

0.092

−0.110

0.358

0.015

0.069

0.571

0.038

0.078

0.524

0.031

 Right

−0.045

0.709

0.069

−0.056

0.643

0.054

0.112

0.358

0.031

−0.051

0.680

0.062

  1. Associations between regional white matter hyperintensity volumes and neuropsychiatric symptoms were assessed using linear regression analyses. Estimates are presented as standardized β values to allow for comparison of effect sizes. Model: age, sex, vascular risk factors, and corresponding regional grey matter atrophy as covariates
  2. *Significant result following Benjamini-Hochberg FDR correction for all correlational tests
  3. Abbreviations: FDR false discovery rate, NPI Neuropsychiatric Inventory