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Table 2 Linear regression between white matter hyperintensities and neuropsychiatric symptoms across all subgroups

From: White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Neuropsychiatric symptom

Total NPI

Delusion

Hallucination

Agitation

Depression

Region

β

coefficient

Unadjusted P value

FDR

q value

β

coefficient

Unadjusted P value

FDR

q value

β

coefficient

Unadjusted P value

FDR

q value

β

coefficient

Unadjusted P value

FDR

q value

β

coefficient

Unadjusted P value

FDR

q value

Total

0.212

0.080

0.023

0.138

0.271

0.038

−0.116

0.358

0.054

0.077

0.540

0.085

0.267

0.028

0.008

Deep matter

0.197

0.093

0.023

0.161

0.186

0.038

−0.083

0.495

0.077

−0.040

0.741

0.100

0.115

0.337

0.062

Periventricular

0.201

0.099

0.023

0.126

0.319

0.038

−0.113

0.372

0.054

0.090

0.478

0.062

0.273

0.026

0.008

Frontal

0.330*

0.006*

0.015

0.207

0.099

0.054

0.056

0.956

0.100

0.121

0.338

0.085

0.147

0.236

0.069

 Left

0.267

0.034

0.023

0.257

0.039

0.031

−0.022

0.862

0.100

0.102

0.410

0.085

0.129

0.300

0.069

 Right

0.282

0.017

0.015

0.148

0.253

0.062

0.042

0.741

0.092

0.106

0.409

0.085

0.138

0.279

0.069

Frontal—medial

0.089

0.493

0.046

−0.085

0.531

0.054

0.135

0.314

0.023

0.019

0.892

0.092

−0.054

0.688

0.069

 Left

0.052

0.688

0.046

−0.014

0.917

0.085

0.124

0.357

0.031

0.018

0.896

0.077

0.026

0.851

0.069

 Right

0.095

0.414

0.038

−0.057

0.661

0.085

0.093

0.474

0.046

0.059

0.654

0.077

−0.145

0.272

0.031

Frontal—lateral

0.314*

0.012*

0.008

0.251

0.056

0.031

−0.075

0.566

0.092

0.098

0.470

0.085

0.148

0.258

0.077

 Left

0.263

0.042

0.023

0.280

0.034

0.015

−0.087

0.508

0.085

0.065

0.630

0.100

0.087

0.519

0.092

 Right

0.339*

0.008*

0.015

0.225

0.097

0.046

−0.027

0.839

0.100

0.097

0.484

0.085

0.250

0.067

0.031

Temporal

0.078

0.509

0.069

0.090

0.462

0.062

−0.097

0.426

0.046

0.034

0.782

0.085

0.166

0.166

0.008

 Left

−0.108

0.218

0.008

−0.055

0.651

0.062

−0.032

0.787

0.077

−0.086

0.481

0.023

−0.013

0.915

0.092

 Right

0.195

0.103

0.031

0.139

0.248

0.054

−0.094

0.439

0.077

0.095

0.428

0.069

0.240

0.040

0.008

Parietal

0.109

0.364

0.023

0.039

0.752

0.085

−0.080

0.519

0.038

0.078

0.529

0.046

0.252

0.036

0.008

 Left

0.097

0.423

0.046

0.053

0.663

0.062

−0.070

0.567

0.054

0.125

0.303

0.015

0.120

0.319

0.023

 Right

0.125

0.308

0.031

−0.004

0.974

0.100

−0.058

0.643

0.062

0.022

0.861

0.069

0.326*

0.007*

0.008

Occipital

0.021

0.857

0.085

0.042

0.728

0.069

−0.060

0.622

0.054

0.004

0.977

0.100

0.401*

<0.001*

0.008

 Left

0.039

0.747

0.077

0.053

0.660

0.054

−0.044

0.717

0.069

0.016

0.895

0.100

0.349*

0.003*

0.008

 Right

0.060

0.626

0.038

0.036

0.767

0.077

−0.015

0.898

0.077

0.032

0.793

0.085

0.386*

0.001*

0.008

  1. Associations symptoms were assessed using linear regression analyses. Estimates are presented as standardized β values to allow for comparison of effect sizes. Model: age, sex, vascular risk factors, and corresponding regional gray matter atrophy as covariates
  2. *Significant result following Benjamini-Hochberg FDR correction for all correlational tests
  3. Abbreviations: FDR false discovery rate, NPI Neuropsychiatric Inventory