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Table 2 Linear regression between white matter hyperintensities and neuropsychiatric symptoms across all subgroups

From: White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Neuropsychiatric symptom Total NPI Delusion Hallucination Agitation Depression
Region β
coefficient
Unadjusted P value FDR
q value
β
coefficient
Unadjusted P value FDR
q value
β
coefficient
Unadjusted P value FDR
q value
β
coefficient
Unadjusted P value FDR
q value
β
coefficient
Unadjusted P value FDR
q value
Total 0.212 0.080 0.023 0.138 0.271 0.038 −0.116 0.358 0.054 0.077 0.540 0.085 0.267 0.028 0.008
Deep matter 0.197 0.093 0.023 0.161 0.186 0.038 −0.083 0.495 0.077 −0.040 0.741 0.100 0.115 0.337 0.062
Periventricular 0.201 0.099 0.023 0.126 0.319 0.038 −0.113 0.372 0.054 0.090 0.478 0.062 0.273 0.026 0.008
Frontal 0.330* 0.006* 0.015 0.207 0.099 0.054 0.056 0.956 0.100 0.121 0.338 0.085 0.147 0.236 0.069
 Left 0.267 0.034 0.023 0.257 0.039 0.031 −0.022 0.862 0.100 0.102 0.410 0.085 0.129 0.300 0.069
 Right 0.282 0.017 0.015 0.148 0.253 0.062 0.042 0.741 0.092 0.106 0.409 0.085 0.138 0.279 0.069
Frontal—medial 0.089 0.493 0.046 −0.085 0.531 0.054 0.135 0.314 0.023 0.019 0.892 0.092 −0.054 0.688 0.069
 Left 0.052 0.688 0.046 −0.014 0.917 0.085 0.124 0.357 0.031 0.018 0.896 0.077 0.026 0.851 0.069
 Right 0.095 0.414 0.038 −0.057 0.661 0.085 0.093 0.474 0.046 0.059 0.654 0.077 −0.145 0.272 0.031
Frontal—lateral 0.314* 0.012* 0.008 0.251 0.056 0.031 −0.075 0.566 0.092 0.098 0.470 0.085 0.148 0.258 0.077
 Left 0.263 0.042 0.023 0.280 0.034 0.015 −0.087 0.508 0.085 0.065 0.630 0.100 0.087 0.519 0.092
 Right 0.339* 0.008* 0.015 0.225 0.097 0.046 −0.027 0.839 0.100 0.097 0.484 0.085 0.250 0.067 0.031
Temporal 0.078 0.509 0.069 0.090 0.462 0.062 −0.097 0.426 0.046 0.034 0.782 0.085 0.166 0.166 0.008
 Left −0.108 0.218 0.008 −0.055 0.651 0.062 −0.032 0.787 0.077 −0.086 0.481 0.023 −0.013 0.915 0.092
 Right 0.195 0.103 0.031 0.139 0.248 0.054 −0.094 0.439 0.077 0.095 0.428 0.069 0.240 0.040 0.008
Parietal 0.109 0.364 0.023 0.039 0.752 0.085 −0.080 0.519 0.038 0.078 0.529 0.046 0.252 0.036 0.008
 Left 0.097 0.423 0.046 0.053 0.663 0.062 −0.070 0.567 0.054 0.125 0.303 0.015 0.120 0.319 0.023
 Right 0.125 0.308 0.031 −0.004 0.974 0.100 −0.058 0.643 0.062 0.022 0.861 0.069 0.326* 0.007* 0.008
Occipital 0.021 0.857 0.085 0.042 0.728 0.069 −0.060 0.622 0.054 0.004 0.977 0.100 0.401* <0.001* 0.008
 Left 0.039 0.747 0.077 0.053 0.660 0.054 −0.044 0.717 0.069 0.016 0.895 0.100 0.349* 0.003* 0.008
 Right 0.060 0.626 0.038 0.036 0.767 0.077 −0.015 0.898 0.077 0.032 0.793 0.085 0.386* 0.001* 0.008
  1. Associations symptoms were assessed using linear regression analyses. Estimates are presented as standardized β values to allow for comparison of effect sizes. Model: age, sex, vascular risk factors, and corresponding regional gray matter atrophy as covariates
  2. *Significant result following Benjamini-Hochberg FDR correction for all correlational tests
  3. Abbreviations: FDR false discovery rate, NPI Neuropsychiatric Inventory