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Table 1 Demographic and clinical characteristics

From: White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease

Characteristics FTLD-TDP
(n = 22)
FTLD-tau (Pick's)
(n = 10)
FTLD-tau (CBD)
(n = 11)
FTLD-tau (PSP)
(n = 15)
AD
(n = 15)
HC
(n = 35)
P-values
Age at baseline 66.5 (8.7) 67.4 (9.6) 67.4 (6.6) 71.4 (5.3) 69.1 (10.0) 71.2 (7.8) 0.278
Age at onset of symptoms 63.2 (8.5) 63.5 (11.1) 63.9 (6.0) 68.3 (5.8) 65.6 (10.5) .. 0.454
Disease duration at baseline assessment (years) 3.9 (3.7) 3.9 (3.7) 3.6 (1.7) 3.1 (1.7) 3.6 (2.2) .. 0.903
Age at imaging 68.2 (7.6) 67.8 (9.8) 68.1 (6.2) 72.0 (5.0) 69.5 (10.5) 71.6 (7.5) 0.059
Age at death 73.1 (10.5) 74.9 (8.0) 71.1 (5.9) 76.4 (5.3) 74.5 (10.5) .. 0.612
Female 10 (45%) 4 (40%) 8 (73%) 6 (40%) 5 (33%) 14 (40%) 0.455
Handedness (R/L/A) 17/4/1 7/2/1 10/1/0 13/1/1 15/0/0 16/0/1 0.512
Education (years) 15.0 (3.2) 15.4 (4.1) 13.5 (3.2) 15.3 (3.2) 16.0 (5.5) 14.4 (3.3) 0.570
MMSE (/30) 22.7 (6.3) 16.9 (10.6) 21.9 (5.8) 24.1 (6.2) 19.9 (6.4) 28.9 (0.9) <0.0001*
DRS (/144) 108.0 (21.1) 102.6 (36.9) 103.4 (25.2) 115.4 (18.9) 110.9 (21.2) 140.5 (2.6) <0.0001*
Total NPI (/144) 25.1 (10.9) 42.2 (23.7) 18.3 (18.6) 14.7 (15.1) 11.9 (8.0) .. <0.0001*
Vascular risk factors
 Hypertension 6 (27%) 2 (20%) 3 (27%) 5 (33%) 4 (27%) 9 (26%) 0.972
 Hyperlipidemia 5 (23%) 0 (0%) 3 (27%) 2 (13%) 6 (40%) 1 (3%) 0.168
 Diabetes mellitus 0 (0%) 1 (10%) 2 (18%) 0 (0%) 0 (0%) 0 (0%) 0.177
 History of stroke/TIA 2 (10%) 1 (10%) 0 (0%) 0 (0%) 1 (6.6%) 0 (0%) 0.705
Total WMH (mm3) 8032 (8889) 3088 (3238) 4179 (4664) 4695 (4872) 4840 (5045) 3053 (11947) 0.058
  1. Data are n (%) and mean (± standard deviation). All percentages were rounded to the nearest whole number
  2. Brain imaging acquisition was performed within 12 weeks of participant’s baseline assessment
  3. *Significant difference between groups (P < 0.05) on ANOVA with post hoc Bonferroni tests for continuous variables, χ2/Fisher Exact Tests for categorical/dichotomous variables, respectively, and Kruskal-Wallis with post hoc Mann-Whitney U tests for non-normally distributed data
  4. Abbreviations: AD Alzheimer’s disease, CBD corticobasal degeneration, DRS Dementia Rating Scale, FTLD frontotemporal lobar degeneration, HC healthy controls, MMSE Mini-Mental State Examination, NPI Neuropsychiatric Inventory, PSP progressive supranuclear palsy, TIA transient ischemic attack, WMH white matter hyperintensity