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Table 3 Variants with significant or suggestive evidence for association with Alzheimer’s disease within 3q13.11

From: Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer’s disease in Caribbean Hispanics

Chr SNP Position Allele Gene Consequence OR (95% CI) P
3 rs1731642 103,811,750 G 38kb 5' of AC016970.1 intergenic 1.33 (1.17—1.53) 6.36E05
3 rs9848147 104,111,719 C 338kb 5' of AC016970.1 intergenic 1.65 (1.302.08) 7.02E−05
3 rs2673478 104,158,244 G 385kb 5' of AC016970.1 intergenic 1.22 (1.091.38) 1.33E−03
3 rs16850638 104,594,467 A 491kb 5' of ALCAM intergenic 0.69 (0.570.84) 4.24E−04
3 rs12492893 104,667,061 A 419kb 5' of ALCAM intergenic 1.23 (1.101.38) 5.45E−04
3 rs9288795 104,683,753 G 402kb 5' of ALCAM intergenic 0.83 (0.740.92) 1.21E−03
3 rs16850772 104,736,837 A 349kb 5' of ALCAM intergenic 1.26 (1.121.41) 1.91E−04
3 rs9883825 104,745,091 G 341kb 5' of ALCAM intergenic 0.80 (0.710.90) 3.55E−04
3 rs13325696 104,755,481 A 330kb 5' of ALCAM intergenic 1.28 (1.131.45) 2.29E−04
3 rs1503079 104,759,032 A 327kb 5' of ALCAM intergenic 0.81 (0.720.91) 4.92E−04
3 rs1566720 104,761,408 A 324kb 5' of ALCAM intergenic 0.82 (0.730.92) 1.13E−03
3 rs1587707 104,786,133 C 300kb 5' of ALCAM intergenic 0.80 (0.710.89) 2.06E−04
3 rs2895295 104,790,415 C 295kb 5' of ALCAM intergenic 0.80 (0.710.90) 2.32E−04
3 rs10933809 104,800,350 A 285kb 5' of ALCAM intergenic 0.79 (0.700.89) 1.19E−04
3 rs1503089 104,805,417 G 280kb 5' of ALCAM intergenic 1.23 (1.091.39) 9.28E−04
3 rs1503075 104,806,853 G 279kb 5' of ALCAM intergenic 0.81 (0.720.92) 1.23E−03
3 rs1503158 104,815,105 G 271kb 5' of ALCAM intergenic 0.80 (0.710.90) 5.52E−04
3 rs13322578 105,002,637 A 83kb 5' of ALCAM intergenic 0.77 (0.660.89) 5.90E−04
3 rs9816851 105,012,805 G 73kb 5' of ALCAM intergenic 0.77 (0.670.89) 6.64E−04
3 rs9860520 106,416,700 A 9.1kb 3' of Y_RNA intergenic 0.79 (0.700.90) 4.28E−4
3 rs12489299 106,985,680 A DUBR intron 0.69 (0.570.83) 1.70E−04
3 rs12494162 107,036,379 A DUBR Intron 0.69 (0.60—0.80) 2.33E06
3 rs7615167 107,514,134 A BBX Intron 1.56 (1.202.02) 1.23E−03
3 rs4855772 107,540,375 G 10kb 3' of BBX intergenic 1.80 (1.312.49) 5.81E−04
  1. Significance thresholds are based on the effective number of independent tests. Abbreviations: Chr = chromosome, SNP = single-nucleotide polymorphism identifier, Position = chromosome 3 position on the GRCh37/hg19 map, Allele = effect allele, OR = odds ratio, significant evidence of association = P < 6.7E-05, suggestive evidence of association = P < 1.4E-03. Significant results are highlighted in bold font