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Table 2 Evidence of association between local ancestry and Alzheimer’s disease in the Caribbean Hispanics

From: Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer’s disease in Caribbean Hispanics

Chr

Position

rsID

Gene

Consequence

Ancestry

OR (95% CI)

P

2q22.2

142,486,253–143,387,612

rs13024316

LRP1B

Intron

EUR

1.28 (1.13−1.45)

6.82E−04

3q13.11

103,747,624–107,725,831

rs10933849

Intergenic

Intergenic

NAM

0.58 (0.47−0.73)

8.76E−07

6q22.31

123,548,997–123,838,033

rs6940177

TRDN

Intron

NAM

1.44 (1.19−1.75)

9.54E−04

8q24.22

135,308,849–135,856,404

rs4308771

RP11-513H8.1

Intron

NAM

1.36 (1.12−1.65)

5.41E−04

9p21.3

22,207,037–22,870,294

rs4977586

Intergenic

Intergenic

NAM

0.70 (0.56−0.87)

4.56E−04

14q12

32,485,703–33,033,695

rs1952961

RP11-187E13.2

Intron

AFR

0.81 (0.71−0.93)

7.24E−04

19p13.3

266,034–1,505,874

rs3787017

PALM

Intron

AFR

1.29 (1.14−1.47)

4.26E−04

  1. Values are given for the SNP with the smallest P value per locus. Definitions: Chr = chromosome, Position = base pair position in NCBI37/hg19 genome build, Lead SNP = single-nucleotide polymorphism with the smallest P value within each LD-block, Ancestry = African (AFR), European (EUR), and Native American (NAM), OR = odds ratio, genome-wide significant evidence for association = P < 5E−05, suggestive evidence for association = P < 0.001. The block with significant evidence for association is highlighted in bold font. All intronic variants are canonical transcripts. Results for each block associated with Alzheimer’s disease at each locus are provided in Additional file 2