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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer’s disease in Caribbean Hispanics

Fig. 4

Colocalization between cis-eQTLs and admixture mapping (a) and association results (b) at 3q13.11. a Colocalization results between significant admixture mapping haplotypes and eQTLs from dorsolateral prefrontal cortex (DLPFC) data. The color scale depicts extent of linkage disequilibrium (LD) with the lead cis-eQTL (rs12629430, purple diamond) in the 1000 Genomes Native American sample, which falls within a significant haplotype block. b Colocalization results between association test of 3q13.11 and cis-eQTLs from DLPFC data. The color scale depicts the amount of LD with the lead SNP from the association tests (rs12494162, purple diamond), based on 1000 Genomes Native American samples. The lead SNP rs1249162 is a significant cis-eQTL in the DLPFC data. Note: the difference in eQTL plots between panels a and b are due to differences in SNP marker density between admixture mapping and association testing

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Alzheimer's Research & Therapy

ISSN: 1758-9193