Fig. 1

Comparison of CSF p-tau, t-tau, NfL, and neurogranin between Aβ groups. The boxplots depict the median (horizontal bar), interquartile range (IQR hinges), and 1.5 × IQR (whiskers). Group differences were assessed by a one-way analysis of covariance (ANCOVA) adjusted by age and sex, followed by Dunnett-corrected pairwise post hoc comparisons. We show the percentage of increase in the mean of each biomarker in the low burden group compared to the Aβ- group. The percentage is shown in bold if the difference is statistically significant. “Low burden” refers to “low burden of Aβ pathology”. NS, not significant. *P <0.05; **P <0.01; ***P <0.001; ****P <0.0001