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Table 4 Statistically significant DEmiRNAs identified by the meta-analysis in subgroup analysis

From: Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer’s disease by meta-analysis and adaptive boosting ensemble learning

Blood elements miRNA Comparison ID Number of upregulated case in AD Number of downregulated case in AD Number of control case Weight P value FDR LogOR 95% CI τ^2 I^2
Whole blood miR-107 27501295_WB   172 109 50.26% 1.03E−12 2.06E−12 − 10.12 [− 12.91, − 7.34] 0.00 0.00%
23895045_WB   94 21 49.74%       
Plasma miR-103a-3p 28179587_Pla_AD2   13 9 49.64% 0.000266 0.00031 − 8.62 [− 13.26, − 3.99] 7.09 63.36%
31420923_Pla   120 120 50.36%       
miR-107 25742200_Pla   97 81 49.96% 5.26E−14 3.68E−13 − 10.67 [− 13.45, − 7.89] 0.00 0.00%
31420923_Pla   120 120 50.04%       
miR-200a-3p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 4.72E−05 6.01 [3.17, 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%       
miR-483-5p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 4.72E−05 6.01 [3.17, 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%       
miR-486-5p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 4.72E−05 6.01 [3.17, 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%       
miR-502-3p 28179587_Pla_AD2 13   9 50.26% 3.37E−05 4.72E−05 6.01 [3.17, 8.85] 0.00 0.00%
28179587_Pla_MCI-AD2 8   9 49.74%       
Serum miR-106b-3p 29036818_Ser_Mild 31   86 24.98% 1.05E−20 9.08E−20 9.38 [7.41, 11.35] 0.00 0.00%
29036818_Ser_Mod 52   86 25.06%       
29036818_Ser_Sev 38   86 25.01%       
28626163_Ser 45   40 24.96%       
miR-126-5p 29036818_Ser_Mild   31 86 33.28% 2.06E−16 7.01E−16 − 9.53 [− 11.81, − 7.26] 0.00 0.00%
29036818_Ser_Mod   52 86 33.39%       
29036818_Ser_Sev   38 86 33.33%       
miR-148b-5p 29036818_Ser_Mild   31 86 33.28% 2.06E−16 7.01E−16 − 9.53 [− 11.81, − 7.26] 0.00 0.00%
29036818_Ser_Mod   52 86 33.39%       
29036818_Ser_Sev   38 86 33.33%       
miR-181c-3p 29036818_Ser_Mild   31 86 33.28% 2.06E−16 7.01E−16 − 9.53 [− 11.81, − 7.26] 0.00 0.00%
29036818_Ser_Mod   52 86 33.39%       
29036818_Ser_Sev   38 86 33.33%       
miR-181c-5p 24139697_Ser   105 155 50.39% 0.00354 0.008598 − 8.28 [− 13.84, − 2.71] 11.96 74.29%
22155483_Ser   7 7 49.61%       
miR-22-3p 29036818_Ser_Mild   31 86 24.98% 1.07E−20 9.08E−20 − 9.38 [− 11.34, − 7.41] 0.00 0.00%
29036818_Ser_Mod   52 86 25.06%       
29036818_Ser_Sev   38 86 25.01%       
29746584_Ser   47 38 24.95%       
miR-93-5p 26078483_Ser   79 75 50.13% 2.30E−11 6.53E−11 − 9.50 [− 12.28, − 6.71] 0.00 0.00%
28626163_Ser   45 40 49.87%       
miR-222-3p 28849039_Ser_Mil   30 30 50.00% 8.09E−09 2.08E−08 − 8.22 [− 11.02, − 5.43] 0.00 0.00%
28849039_Ser_Mod   30 30 50.00%       
PBMC miR-128-3p 27239545_PBMC 30   30 33.28% 3.94E−13 3.94E−13 8.44 [6.16, 10.72] 0.00 0.00%
24064186_PBMC_Mon 34   37 33.36%       
24064186_PBMC_Lym 34   37 33.36%