Table 4 Statistically significant DEmiRNAs identified by the meta-analysis in subgroup analysis
Blood elements | miRNA | Comparison ID | Number of upregulated case in AD | Number of downregulated case in AD | Number of control case | Weight | P value | FDR | LogOR | 95% CI | τ^2 | I^2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Whole blood | miR-107 | 27501295_WB | 172 | 109 | 50.26% | 1.03E−12 | 2.06E−12 | − 10.12 | [− 12.91, − 7.34] | 0.00 | 0.00% | |
23895045_WB | 94 | 21 | 49.74% | |||||||||
Plasma | miR-103a-3p | 28179587_Pla_AD2 | 13 | 9 | 49.64% | 0.000266 | 0.00031 | − 8.62 | [− 13.26, − 3.99] | 7.09 | 63.36% | |
31420923_Pla | 120 | 120 | 50.36% | |||||||||
miR-107 | 25742200_Pla | 97 | 81 | 49.96% | 5.26E−14 | 3.68E−13 | − 10.67 | [− 13.45, − 7.89] | 0.00 | 0.00% | ||
31420923_Pla | 120 | 120 | 50.04% | |||||||||
miR-200a-3p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 4.72E−05 | 6.01 | [3.17, 8.85] | 0.00 | 0.00% | ||
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% | |||||||||
miR-483-5p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 4.72E−05 | 6.01 | [3.17, 8.85] | 0.00 | 0.00% | ||
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% | |||||||||
miR-486-5p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 4.72E−05 | 6.01 | [3.17, 8.85] | 0.00 | 0.00% | ||
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% | |||||||||
miR-502-3p | 28179587_Pla_AD2 | 13 | 9 | 50.26% | 3.37E−05 | 4.72E−05 | 6.01 | [3.17, 8.85] | 0.00 | 0.00% | ||
28179587_Pla_MCI-AD2 | 8 | 9 | 49.74% | |||||||||
Serum | miR-106b-3p | 29036818_Ser_Mild | 31 | 86 | 24.98% | 1.05E−20 | 9.08E−20 | 9.38 | [7.41, 11.35] | 0.00 | 0.00% | |
29036818_Ser_Mod | 52 | 86 | 25.06% | |||||||||
29036818_Ser_Sev | 38 | 86 | 25.01% | |||||||||
28626163_Ser | 45 | 40 | 24.96% | |||||||||
miR-126-5p | 29036818_Ser_Mild | 31 | 86 | 33.28% | 2.06E−16 | 7.01E−16 | − 9.53 | [− 11.81, − 7.26] | 0.00 | 0.00% | ||
29036818_Ser_Mod | 52 | 86 | 33.39% | |||||||||
29036818_Ser_Sev | 38 | 86 | 33.33% | |||||||||
miR-148b-5p | 29036818_Ser_Mild | 31 | 86 | 33.28% | 2.06E−16 | 7.01E−16 | − 9.53 | [− 11.81, − 7.26] | 0.00 | 0.00% | ||
29036818_Ser_Mod | 52 | 86 | 33.39% | |||||||||
29036818_Ser_Sev | 38 | 86 | 33.33% | |||||||||
miR-181c-3p | 29036818_Ser_Mild | 31 | 86 | 33.28% | 2.06E−16 | 7.01E−16 | − 9.53 | [− 11.81, − 7.26] | 0.00 | 0.00% | ||
29036818_Ser_Mod | 52 | 86 | 33.39% | |||||||||
29036818_Ser_Sev | 38 | 86 | 33.33% | |||||||||
miR-181c-5p | 24139697_Ser | 105 | 155 | 50.39% | 0.00354 | 0.008598 | − 8.28 | [− 13.84, − 2.71] | 11.96 | 74.29% | ||
22155483_Ser | 7 | 7 | 49.61% | |||||||||
miR-22-3p | 29036818_Ser_Mild | 31 | 86 | 24.98% | 1.07E−20 | 9.08E−20 | − 9.38 | [− 11.34, − 7.41] | 0.00 | 0.00% | ||
29036818_Ser_Mod | 52 | 86 | 25.06% | |||||||||
29036818_Ser_Sev | 38 | 86 | 25.01% | |||||||||
29746584_Ser | 47 | 38 | 24.95% | |||||||||
miR-93-5p | 26078483_Ser | 79 | 75 | 50.13% | 2.30E−11 | 6.53E−11 | − 9.50 | [− 12.28, − 6.71] | 0.00 | 0.00% | ||
28626163_Ser | 45 | 40 | 49.87% | |||||||||
miR-222-3p | 28849039_Ser_Mil | 30 | 30 | 50.00% | 8.09E−09 | 2.08E−08 | − 8.22 | [− 11.02, − 5.43] | 0.00 | 0.00% | ||
28849039_Ser_Mod | 30 | 30 | 50.00% | |||||||||
PBMC | miR-128-3p | 27239545_PBMC | 30 | 30 | 33.28% | 3.94E−13 | 3.94E−13 | 8.44 | [6.16, 10.72] | 0.00 | 0.00% | |
24064186_PBMC_Mon | 34 | 37 | 33.36% | |||||||||
24064186_PBMC_Lym | 34 | 37 | 33.36% |