Fig. 5

sAη–α acutely lowers LTP in vivo. a LTP was measured in vivo in the dentate gyrus of Sprague-Dawley rats. Summary graphs of fEPSP slope (% baseline) pre- and post-LTP induction (time 0) upon 10 min of intra-hippocampal injection of 1 μM of control peptide (sAη–β–CT) or sAη–α. Injection time is shown by the black bar. Note a transient decline and partial recovery of baseline responses upon the injection and a subsequent LTP induction. b Summary of fEPSP magnitude 1–10 min after LTP induction as fEPSP (% baseline) for data shown in a. c Summary of fEPSP magnitude 50–60 min after LTP induction as fEPSP (% baseline) for data shown in a. All recordings were done in vivo in Sprague Dawley rats with n= number of rats. *p< 0.05 Detailed statistics are shown in Supplementary Table S5