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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo

Fig. 3

N-terminal of Aη is necessary and sufficient for LTP impairment. a Diagram showing APP processing (secretases cleavage sites are shown) and boundaries of shorter synthetic peptides used to identify the active site. b–e LTP was analyzed ex vivo at CA3-CA1 synapse in hippocampal slices of RjOrl:SWISS mice. Summary graphs of b, d fEPSP slope (% baseline) pre- and post-LTP induction (time 0) and c, e fEPSP magnitude 45–60 min after LTP induction in control (aCSF only) or in presence of b, c 100 nM sAη–NT or sAη–β-CT or d, e of 10 nM sAη–NT, throughout the recording (n= slices, N= mice), *p< 0.05. Detailed statistics are shown in Supplementary Table S3

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Alzheimer's Research & Therapy

ISSN: 1758-9193