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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo

Fig. 1

Synthetic Aη-α and Aη-β acutely inhibit LTP within the low nanomolar range. LTP was analyzed ex vivo at CA3-CA1 synapse in hippocampal slices of RjOrl:SWISS mice. a, c, e, and g Summary graphs of fEPSP slope (% baseline) pre- and post-LTP induction (time 0) in control (aCSF only) or in presence of a 100 nM sAη–β, c 10 nM sAη–α or sAη–β, e 5 nM sAη–α or sAη–β, and g 1 nM sAη–α or sAη–β, throughout the recording. b, d, f, and h Summary of fEPSP magnitude 45–60 min after LTP induction as fEPSP (% baseline) for data shown in a, c, e, and g, respectively (n= slices, N= mice), *p< 0.05, **p< 0.01, ***p< 0.001. Detailed statistics are shown in Supplementary Table S1

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