EOAD | LOAD | |||||
---|---|---|---|---|---|---|
Cognitive domain | Beta (SE) | p value | Beta (SE) | p value | p value^ (risk factor*time*onset age group) | p value^^, multivariable analysis (risk factor*time*onset age group) |
Language | ||||||
APOE ε4 carrier*time | 0.130 (0.050) | 0.010 | 0.003 | 0.005a$ | ||
Memory | ||||||
APOE ε4 carrier*time | 0.131 (0.059) | 0.027 | 0.006 | 0.011b$ | ||
High education*time | − 0.094 (0.060) | 0.122 | ||||
Diabetes*time | − 0.073 (0.032) | 0.021 | 0.083 | |||
Dyslipidemia*time | 0.132 (0.065) | 0.044 | 0.030 | 0.055b | ||
Frontal | ||||||
APOE ε4 carrier*time | 0.139 (0.044) | 0.002 | 0.005 | 0.053c | ||
High education*time | − 0.169 (0.045) | < .001 | − 0.047 (0.029) | 0.110 | 0.017 | 0.030c |
Hypertension*time | − 0.065 (0.027) | 0.016 | 0.005 | 0.016c$ | ||
Diabetes*time | − 0.062 (0.029) | 0.032 | 0.572 | |||
BMI*time (ref:normal weight) | ||||||
Underweight | − 0.197 (0.071) | 0.006 | 0.759 | |||
Overweight | 0.015 (0.033) | 0.653 | 0.746 | |||
Obesity | 0.023 (0.032) | 0.460 | 0.263 | |||
MMSE | ||||||
APOE ε4 carrier*time | 0.063 (0.024) | 0.011 | 0.024 | 0.026d | ||
High education*time | − 0.033 (0.014) | 0.017 | 0.655 | |||
Hypertension*time | 0.087 (0.027) | 0.002 | − 0.022 (0.012) | 0.076 | < .001 | < .001d$ |
CDR (sum of boxes) | ||||||
APOE ε4 carrier*time | − 0.005 (0.002) | 0.010 | 0.230 | |||
BMI*time (ref:normal weight) | 0.022e$ | |||||
Underweight | − 0.006 (0.006) | 0.304 | 0.240 | 0.264 | ||
Overweight | − 0.001 (0.002) | 0.576 | 0.959 | 0.796 | ||
Obesity | − 0.007 (0.003) | 0.012 | 0.006 | 0.008 |