Table 1 Baseline demographics of patients with Alzheimer’s disease by onset age
All participants | EOAD | LOAD | p value for EOAD vs. LOAD | |
|---|---|---|---|---|
No. | 669 | 193 | 476 | |
Baseline age, years | 72.41 ± 8.20 | 61.97 ± 5.64 | 76.64 ± 4.41 | < 0.001 |
Onset age, years | 69.05 ± 9.25 | 57.31 ± 5.30 | 73.81 ± 5.51 | < 0.001 |
Female sex | 436 (65.17) | 126 (65.28) | 310 (65.13) | 0.969 |
Low education (≤ 12 years)* | 479 (71.60) | 125 (64.77) | 354 (74.37) | 0.013 |
APOE ε4 carrier | 341(50.97) | 107 (55.44) | 234 (49.16) | 0.141 |
Hypertension | 282 (42.15) | 54 (27.99) | 228 (47.90) | < 0.001 |
Diabetes | 161 (24.07) | 36 (18.65) | 125 (26.26) | 0.037 |
Dyslipidemia | 184 (27.50) | 52 (26.94) | 132 (27.73) | 0.836 |
BMI | ||||
Underweight (< 18.5) | 27 (4.04) | 6 (3.11) | 21 (4.41) | 0.002 |
Normal weight (≤18.5 ~ < 23) | 271 (40.51) | 85 (44.04) | 186 (39.08) | |
Over weight (23 ≤ ~ < 25) | 182 (27.20) | 65 (33.68) | 115 (24.16) | |
Obesity (≥ 25) | 189 (28.25) | 37 (19.17) | 154 (32.35) | |
K-MMSE | 20.97 ± 3.96 | 20.68 ± 3.69 | 21.08 ± 4.06 | 0.240 |
CDR-SB | 4.58 ± 2.11 | 4.38 ± 2.18 | 4.66 ± 2.08 | 0.121 |
Language | 33.37 ± 10.71 | 39.02 ± 10.66 | 31.07 ± 9.86 | < 0.001 |
Visuospatial | 24.07 ± 9.82 | 21.32 ± 11.20 | 25.19 ± 8.97 | < 0.001 |
Memory | 49.11 ± 11.42 | 50.96 ± 11.48 | 48.36 ± 11.32 | 0.008 |
Frontal | 22.38 ± 9.86 | 22.60 ± 10.71 | 22.29 ± 9.50 | 0.713 |
Follow-up periods, months | 32.38 ± 23.19 | 31.06 ± 22.31 | 32.91 ± 23.54 | 0.352 |