Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease

Table 2 Relationship between awareness and AD biomarkers

	Participants-informants								Objective-subjective
	SUVr tau entorhinal			SUVr tau inferior temporal					SUVr tau entorhinal			SUVr tau inferior temporal
Vars	Estimate	SD	ESs	P	Estimate	SD	ESs	P	Estimate	SD	ESs	P	Estimate	SD	ESs	P
(Intercept)	0.38	0.47			0.52	0.47			0.71	0.97			0.75	0.99
Age	0	0.01	0	1.000	0	0.01	0	1.000	−0.02	0.01	0.011	0.090	−0.02	0.01	0.009	0.115
Gender	−0.13	0.08	0.008	0.200	−0.12	0.08	0.007	0.245	−0.27	0.16	0.009	0.192	−0.27	0.16	0.008	0.208
Education	0	0.01	0	1.000	0	0.01	0	1.000	0.07	0.03	0.015	0.058	0.06	0.03	0.012	0.101
Clinical status			0	0.787			0.003	0.249			0.006	0.574			0.002	1.000
Clinical StatusImpaired	−0.04	0.09			−0.09	0.09			0.26	0.19			0.15	0.19
Amyloid	0.12	0.05	0	0.927	0.11	0.05	0	0.659	0.36	0.11	0	0.583	0.37	0.12	0	0.577
Tau	−0.07	0.07	0	0.037*	−0.02	0.1	0	0.023*	−0.17	0.14	0	0.081	−0.23	0.21	0	0.243
Clinical Status:Amyloid			0.004	0.201			0.005	0.408			0.014	0.019*			0.032	0.003*
Clinical StatusImpaired:Amyloid	−0.1	0.09			−0.1	0.08			−0.4	0.18			−0.58	0.18
Clinical Status:Tau			0	1.000			0.002	1.000			0.001	1.000			0.004	0.704
Clinical StatusImpaired:Tau	0.02	0.09			0.09	0.13			0.12	0.19			0.31	0.27
Amyloid:Tau	0.11	0.07	0	0.086	0.11	0.09	0	0.004*	0.17	0.15	0	0.087	0.07	0.2	0	0.347
Clinical Status:Amyloid:Tau			0.023	0.013*			0.015	0.057			0.016	0.046*			0.002	0.839
Clinical StatusImpaired:Amyloid:Tau	−0.22	0.08			−0.22	0.1			−0.38	0.17			−0.17	0.21

Note: SD standard deviation, ESs effect sizes (Cohen’s f2), Amyloid florbetapir PET SUVr, Tau flortaucipir PET SUVr

ISSN: 1758-9193