Fig. 1
From: Pathological correlates of impaired self-awareness of memory function in Alzheimer’s disease
AD biomarkers’ influence on awareness (participant vs informant) among clinical stages. Notes: This figure presents the projected values of awareness within the different clinical groups (i.e., normal and impaired on the left and right panels, respectively) as predicted by both Tau SUVr (A entorhinal cortex, B inferior temporal cortex) and amyloidosis (for low, medium, and high levels of amyloid burden; represented in yellow, gray, and green, respectively). Results from the entorhinal cortex (line A) showed a significant interaction between both biomarkers (p = 0.013), with amyloid-negative clinically normal participants showing a lower awareness associated with greater tau burden (p = 0.06). In the impaired group, the opposite pattern was observed with a significant negative relationship for the participant with higher amyloid burden (p = 0.01). The model using the inferior temporal tau burden showed only a trending interaction (p = 0.057)