Fig. 2
From: Race, APOE genotypes, and cognitive decline among middle-aged urban adults
APOE4 allelic dosage vs. CVLT-List A trajectories among Whites and African Americans: predictive margins from mixed-effects linear regression modela. Abbreviations: APOE = Apolipoprotein E; CVLT-List A = California Verbal Learning Test, List A; HANDLS = Healthy Aging in Neighborhoods of Diversity across the Life Span. a Model 2B, Table 2, fully adjusted model, stratified by race. Figure shows predictive margins of CVLT-List A scores across time, highlighting the significant difference in slope across APOE4 dosage among Whites only. γ12 refers to the fixed effect of APOE4 dosage on the rate of change in CVLT-List A total score for each racial group. “b” is a standardized measure for the regression coefficient γ12 in model where CVLT-LIST A is entered as standardized z-scores within each racial group. It is interpreted as the SD of outcome change per year increase in follow-up time for each APOE4 dosage change. 1 SD of CVLT-LIST A corresponds to 7.71 change in score, overall