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Table 1 Demographics of study participants

From: Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population

 

Discovery data

Replication data

 

Demographics

Total (n = 1190)

Aβ negative (n = 561)

Aβ positive (n = 629)

p†

Total (n = 284)

Aβ negative (n = 180)

Aβ positive (n = 104)

p†

p††

Age, year (SD)

70.07 (8.75)

70.06 (8.16)

70.07 (9.25)

0.990

72.67 (7.32)

71.76 (7.31)

74.25 (7.10)

0.006

< 0.001

Female, n (%)

680 (57.1)

310 (55.3)

370 (58.8)

0.215

184 (64.8)

122 (67.8)

62 (59.6)

0.165

0.019

Education, year (SD)

11.02 (4.86)

10.89 (5.04)

11.13 (4.70)

0.390

8.34 (5.21)

7.77 (5.19)

9.11 (5.15)

0.050

< 0.001

Diagnosis, n (%)

 CU

383 (32.2)

326 (58.1)

57 (9.1)

< 0.001

46 (16.2)

43 (23.9)

3 (2.9)

< 0.001

< 0.001

 aMCI

330 (27.7)

172 (30.7)

158 (25.1)

 

167 (58.8)

125 (69.4)

42 (40.4)

  

 ADD

477 (40.1)

63 (11.2)

414 (65.8)

 

71 (25.0)

12 (6.7)

59 (56.7)

  
  1. †P value was calculated by comparing Aβ negative and Aβ positive participants. ††P value was calculated by comparing discovery data and replication data. Student’s t test and chi-squared test were used for continuous and categorical variables, respectively.
  2. Abbreviations: Aβ amyloid β, ADD Alzheimer’s disease dementia, aMCI amnestic mild cognitive impairment, CU cognitive unimpaired, SD standard deviation