| Discovery data | Replication data |  | ||||||
---|---|---|---|---|---|---|---|---|---|
Demographics | Total (n = 1190) | Aβ negative (n = 561) | Aβ positive (n = 629) | p†| Total (n = 284) | Aβ negative (n = 180) | Aβ positive (n = 104) | p†| p††|
Age, year (SD) | 70.07 (8.75) | 70.06 (8.16) | 70.07 (9.25) | 0.990 | 72.67 (7.32) | 71.76 (7.31) | 74.25 (7.10) | 0.006 | < 0.001 |
Female, n (%) | 680 (57.1) | 310 (55.3) | 370 (58.8) | 0.215 | 184 (64.8) | 122 (67.8) | 62 (59.6) | 0.165 | 0.019 |
Education, year (SD) | 11.02 (4.86) | 10.89 (5.04) | 11.13 (4.70) | 0.390 | 8.34 (5.21) | 7.77 (5.19) | 9.11 (5.15) | 0.050 | < 0.001 |
Diagnosis, n (%) | |||||||||
 CU | 383 (32.2) | 326 (58.1) | 57 (9.1) | < 0.001 | 46 (16.2) | 43 (23.9) | 3 (2.9) | < 0.001 | < 0.001 |
 aMCI | 330 (27.7) | 172 (30.7) | 158 (25.1) |  | 167 (58.8) | 125 (69.4) | 42 (40.4) |  |  |
 ADD | 477 (40.1) | 63 (11.2) | 414 (65.8) |  | 71 (25.0) | 12 (6.7) | 59 (56.7) |  |  |