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Table 1 Participant demographics and clinical characteristics

From: Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia

Variable

Total sample, N = 193, mean ± SD or number (%)

Age

74.9 ± 5.9

Female

102 (53%)

Education

16.7 ± 2.4

APOE ε4+

78 (40%)

Hispanic

18 (10%)

DRS

138.9 ± 4.3

MMSE

29.1 ± 1.3

CDR sum of boxes

0.3 ± 0.7

GDS

1.2 ± 1.7

Clinical Dx: normal

167 (87%)

Clinical Dx: MCI

26 (13%)

FSRP (%)

10.3 ± 7.9

Systolic BP

131.7 ± 18.6

Diastolic BP

80.4 ± 11.2

Pulse pressure

51.2 ± 13.9

PWV

8.9 ± 2.1

TIA

3 (2%)

Atrial fibrillation

20 (10%)

Diabetes

12 (6%)

CVD

27 (14%)

Smoking

4 (2%)

Antihypertensive medication use

94 (49%)

BMI

26.0 ± 5.6

N with CSF measures

123 (64%)

Interval from LP to PWV collection (years)

1.2 ± 0.9

42

812.2 ± 378.6

Tau

358.8 ± 190.1

AD-like tau/Aβ42 ratio

42 (34%)

  1. Abbreviations: CN cognitively normal, MCI mild cognitive impairment, SD standard deviation, APOE apolipoprotein E, DRS Dementia Rating Scale, MMSE Mini-Mental State Examination, CDR Clinical Dementia Rating Scale, GDS Geriatric Depression Scale, FSRP Framingham Stroke Risk Profile, bp blood pressure. Pulse pressure was calculated as systolic blood pressure minus diastolic blood pressure. PWV pulse wave velocity, CVD cardiovascular disease, BMI body mass index, CSF cerebrospinal fluid, Tau total tau; AD Alzheimer’s disease, amyloid beta