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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

Fig. 3

Neuroinflammation-mediated association between COVID-19 and Alzheimer's disease (AD). The expression of AD a blood and b cerebrospinal fluids (CSF) protein markers in COVID-19 patients. Heatmaps show the fold change (FC) of the comparisons indicated above. c, d Network analyses of the AD markers that are differentially expressed in COVID-19 vs. non-COVID-19. Neighbors of these markers that are the SARS-CoV-2 host factors (non-circle nodes) or are DEGs (denoted by “+”) in the COVID-19 datasets are shown. Node shape indicates the number of SARS-CoV-2 host factor datasets that contain the node. Edge colors indicate the protein-protein interaction source type. PBMC, peripheral blood mononuclear cells. DEG, differentially expressed genes. ICU, intensive care unit

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Alzheimer's Research & Therapy

ISSN: 1758-9193